Results 141 to 150 of about 22,758,962 (282)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Shift-adjusted Neyman-Pearson classifiers via single index modeling (SACSIM). [PDF]

Biometrics
Qiu J, Zhao YQ, Zheng Y.
europepmc   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Machine Learning-Assisted SHG Morphometry Reveals Distinct Collagen Microarchitectures of Trabecular Bone and Fibrosis in Bone Marrow Biopsies. [PDF]

Int J Mol Sci
Asaulenko ZP, Egorchev AA, Peshekhonov DA, Nurullin LF, Melnikova AA, Rosin AA, Vedischeva DS, Shaidullin SM, Vafin II, Buchaka AS, Gladyshev NS, Fedchenko ME, Chickrin DE, Krivolapov YA, Samigullin DV, Aganov AV, Paveliev M.   +16 more
europepmc   +1 more source

Ciruvis: a web-based tool for rule networks and interaction detection using rule-based classifiers. [PDF]

BMC Bioinformatics, 2014
Bornelöv S, Marillet S, Komorowski J.
europepmc   +1 more source

RUMC: A Rule-based Classifier Inspired by Evolutionary Methods

CoRR
As the field of data analysis grows rapidly due to the large amounts of data being generated, effective data classification has become increasingly important. This paper introduces the RUle Mutation Classifier (RUMC), which represents a significant improvement over the Rule Aggregation ClassifiER (RACER).
openaire   +3 more sources

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

DKFraudNet: a knowledge-guided adversarial learning framework for fraud user detection. [PDF]

Front Big Data
Shen Y, Shi R, Song K, Li Y.
europepmc   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Artificial intelligence in prior authorization and coverage decisions: A systematic review of methods, evidence gaps, and future implications for patient access. [PDF]

J Manag Care Spec Pharm
Mousavi T, Tohme Shaya F, Cooke CE.
europepmc   +1 more source