Results 261 to 270 of about 328,604 (299)

Polyplex Nanomicelle‐Mediated Pgc‐1α4 mRNA Delivery Via Hydrodynamic Limb Vein Injection Enhances Damage Resistance in Duchenne Muscular Dystrophy Mice

Advanced Science, EarlyView.
This study presents a novel approach for treating Duchenne muscular dystrophy using mRNA encoding PGC‐1α4. Nanomicelle‐delivered Pgc‐1α4 mRNA enhances muscle damage resistance and mitochondrial activity in dystrophic muscles. This study demonstrates the potential of mRNA therapy for neuromuscular diseases like Duchenne muscular dystrophy and highlights
Xuan Du, Hideyuki Nakanishi, Takashi Yamada, Yooksil Sin, Katsura Minegishi, Norio Motohashi, Yoshitsugu Aoki, Keiji Itaka   +7 more
wiley   +1 more source

The intersection of digital health and artificial intelligence: Clearing the cloud of uncertainty. [PDF]

Digit Health
Graili P, Farhoudi B.
europepmc   +1 more source

Oral Microalgae‐Based Biosystem to Enhance Irreversible Electroporation Immunotherapy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study presents an innovative oral microalgae‐based biosystem to inhibit tumor growth, reduce PD‐1 expression, and activate immune responses of hepatocellular carcinoma. When combined with enhanced irreversible electroporation treatment, it demonstrates a synergistic effect that effectively reduces the tumor burden and enhances the tumor immune ...
Cheng Zeng, Shiyuan Hua, Jiayu Zhou, Tangye Zeng, Jianke Chen, Lijian Su, Angfeng Jiang, Min Zhou, Zhe Tang   +8 more
wiley   +1 more source

Predicting postoperative nausea and vomiting using machine learning: a model development and validation study. [PDF]

BMC Anesthesiol
Glebov M, Lazebnik T, Katsin M, Orkin B, Berkenstadt H, Bunimovich-Mendrazitsky S.   +5 more
europepmc   +1 more source

Improved Efficacy of Triple‐Negative Breast Cancer Immunotherapy via Hydrogel‐Based Co‐Delivery of CAR‐T Cells and Mitophagy Agonist

Advanced Science, EarlyView.
Trop2‐targeted CAR‐T cells experienced reduced efficacy and functional exhaustion at a low E:T ratio caused by mitophagy‐mediated mitochondrial dysfunction. Next, the mitophagy is screened agonist BC1618, which significantly strengthened the antitumor response of CAR‐T cells via improving the level of mitophagy, suggesting a promising approach to ...
Guodong Li, Ruoxin Du, Donghui Wang, Xiangmei Zhang, Lizhuo Wang, Shuangpeng Pu, Xiaoju Li, Shuning Wang, Juliang Zhang, Beichen Liu, Yuan Gao, Huadong Zhao   +11 more
wiley   +1 more source

UniMap: Type‐Level Integration Enhances Biological Preservation and Interpretability in Single‐Cell Annotation

Advanced Science, EarlyView.
UniMap introduces a novel multiselective adversarial network that functions as a discerner in single‐cell dataset integration. It enables type‐level integration, ensuring accurate cell type annotation across diverse biological contexts while preserving shared and domain‐specific features.
Haitao Hu, Yue Guo, Fujing Ge, Hao Yin, Hao Zhang, Zhesheng Zhou, Fangjie Yan, Qing Ye, Jialu Wu, Ji Cao, Chang‐Yu Hsieh, Bo Yang   +11 more
wiley   +1 more source

Colon Tumor Discrimination Combining Independent Endoscopic Probe-Based Raman Spectroscopy and Optical Coherence Tomography Modalities with Bayes Rule. [PDF]

Int J Mol Sci
Vasquez DL, Kreft C, Latka I, Popp J, Mantke R, Schie IW.   +5 more
europepmc   +1 more source

Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives

Advanced Science, EarlyView.
This review explores the challenges of treating bone and cartilage defects, emphasizing the role of endogenous electric fields in bone and cartilage regeneration. It highlights recent advancements in electroactive biomaterials, including nanogenerators, piezoelectric materials, triboelectric scaffold, and zwitterionic hydrogels.
Yubin Yao, Xi Cui, Shenglong Ding, Ketao Wang, Mingzhu Zhang   +4 more
wiley   +1 more source

Zebrafish identification with deep CNN and ViT architectures using a rolling training window. [PDF]

Sci Rep
Puchalla J, Serianni A, Deng B.
europepmc   +1 more source