Results 111 to 120 of about 2,767,476 (321)

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Automated Rule-Based Checking for the Validation of Accessibility and Visibility of a Building Information Model

, 2015
Client-developed building programs are increasingly burdened with a number of requirements such as building codes, safety, and programming requirements. Managing these requirements ensures the successful performance of subsequent procedures and the high ...
J. K. Lee, Y. C. Lee, Lee, J. K., C. M. Eastman, Eastman, C. M., Lee, Y. C.   +5 more
core   +1 more source

A Hybrid Approach for Reachability Analysis of Complex Software Systems Using Fuzzy Adaptive Particle Swarm Optimization Algorithm and Rule Composition

Mathematical and Computational Applications
Model checking has become a widely used and precise technique for verifying software systems. However, a major challenge in model checking is state space explosion, which occurs due to the exponential memory usage required by the model checker.
Nahid Salimi, Seyfollah Soleimani, Vahid Rafe, Davood Khodadad   +3 more
doaj   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Adaptable rule checking tools for HDL

, 2009
Today’s electronics in aviation (avionics) are more complex than ever before. With higher requirements on safety and reliability and with new SoC (System on Chip) technology, the validation and verification of designs meet new challenges.
Lord, Mikael
core  

MEMS design rule checking: a batch approach for remote operation [PDF]

, 1998
This paper describes a design rule checking (DRC) tool developed as an aid for designing microelectromechanical structures (MEMS) using AutoCAD running on a Windows NT workstation.
Yarberry, Victor R.
core  

Efeitos de instruções sobre respostas de checagem

Psicologia: Teoria e Pesquisa
O estudo teve o objetivo de testar o controle verbal de diferentes instruções sobre respostas de checagem. Dois participantes adultos foram instruídos a separar quatro tipos de sementes misturadas.
Paulo Roberto Abreu, Maria Martha Costa Hübner   +1 more
doaj   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source