Results 91 to 100 of about 2,767,476 (321)
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Restructuring and simplifying rule bases. [PDF]
Rule bases are commonly acquired, by expert and/or knowledge engineer, in a form which is well suited for acquisition purposes. When the knowledge base is executed, however, a different structure may be required. Moreover, since human experts normally do
Vanthienen, Jan, Wets, G, Dries, E
core
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Automated compliance checking using building information models
, 2010 Building designs in the UK are currently checked manually against a frequently changing and increasingly complex set of building regulations. This is a major task for both designers and enforcers, often leading to ambiguity, inconsistency in assessments ...
Greenwood, David +4 more
core
Вестник Российского экономического университета имени Г. В. Плеханова, 2018 Lately we have seen changes in organization of auditors’ work. Focus is made on the complex analysis of finance and business work of the person being audited and, consequently on rejection of total checking and passing-over to checking based on risk ...
Elvira I. Bakhtigozina
doaj +1 more source
FEBS Open Bio, EarlyView.14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source
A synthesis of fuzzy rule-based system verification. [PDF]
The verification of fuzzy rule bases for anomalies has received increasing attention these last few years. Many different approaches have been suggested and many are still under investigation.
Vanthienen, Jan, Wets, G, Viaene, Stijn
core
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Legal compliance checking of autonomous driving with formalized traffic rule exceptions
, 2023 Autonomous driving (AD) systems need to obey traffic rules and sometimes execute critical maneuvers that breach existing rules to ensure safe and rule-compliant driving.
Manas, Kumar, Paschke, Adrian
core +1 more source