Results 71 to 80 of about 2,767,476 (321)
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A Semantic Web and IFC-Based Framework for Automated BIM Compliance Checking
BuildingsIn the architectural design phase, the inspection of design deliverables is critical, yet traditional manual checking methods are time-consuming, labor-intensive, and inefficient, with numerous drawbacks. With the development of BIM technology, automated
Lu Jia +3 more
doaj +1 more source
Journal of Civil Engineering and Management, 2020 With the popularization of Building Information Modeling (BIM) technology, increasing numbers of countries are attempting to introduce BIM into their national building permitting processes.
Inhan Kim +3 more
doaj +1 more source
The evolution of refractive status in Chinese infants during the first year of life and its affected factors [PDF]
International Journal of Ophthalmology, 2017 AIM: To study the evolution of the refractive status and examine the affected factors in infants during the first year of life in a large sample size in China.
Shu-Juan Yu +6 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Graphical Scripting Approach Integrated with Speech Recognition for BIM-Based Rule Checking
, 2018 A building design must satisfy the requirements from diverse sources such as a building code, owner\u27s specifications, design guidelines, and project requirements. Such requirements entail various types of rules and execution plans.
Pedram Ghannad +9 more
core +1 more source
Coalgebraic Satisfiability Checking for Arithmetic $\mu$-Calculi [PDF]
Logical Methods in Computer ScienceThe coalgebraic $\mu$-calculus provides a generic semantic framework for fixpoint logics over systems whose branching type goes beyond the standard relational setup, e.g. probabilistic, weighted, or game-based.
Daniel Hausmann, Lutz Schröder
doaj +1 more source
Axiomatizing GSOS with Predicates [PDF]
Electronic Proceedings in Theoretical Computer Science, 2011 In this paper, we introduce an extension of the GSOS rule format with predicates such as termination, convergence and divergence. For this format we generalize the technique proposed by Aceto, Bloom and Vaandrager for the automatic generation of ground ...
Luca Aceto +3 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source