Results 111 to 120 of about 33,338 (216)

Fatty acid composition and phospholipid types used in infant formulas modifies the establishment of human gut bacteria in germ-free mice [PDF]

open access: yes, 2017
Human milk fat contains high concentrations of medium-chained fatty acids (MCFA) and triacylglycerols emulsified by a sphingomyelin-rich phospholipid membrane (milk phospholipids, MPL).
Bennike, Rikke Mette Guldhammer   +2 more
core   +1 more source

Gut Microbiome Dysbiosis is Associated With Human T‐Lymphotropic Virus Type 1 (HTLV‐1) Infection and Disease Progression to HTLV‐1‐Associated Myelopathy/Tropical Spastic Paraparesis: A Cross‐Sectional Study

open access: yesSmart Medicine, Volume 5, Issue 1, February 2026.
We provide the first comprehensive analysis of changes in the gut bacteriome at different clinical stages of HTLV‐1 infection. HTLV‐1 infection is associated with a dysbiosis that includes reduced bacterial diversity and an inverted Firmicutes/Bacteroidetes ratio.
Lorena Abreu Fernandes   +8 more
wiley   +1 more source

APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer’s disease pathophysiology [PDF]

open access: yes, 2019
Apolipoprotein E (APOE) genotype is the strongest prevalent genetic risk factor for Alzheimer’s disease (AD). Numerous studies have provided insights into the pathologic mechanisms.
Corsini, Simone   +10 more
core   +1 more source

The Role of the Gut Microbiome in the Complex Network of Frailty Syndrome and Associated Comorbidities in Aging

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
This study analyzed gut microbiota in older adults with and without Frailty Syndrome by 16S rRNA gene sequencing and metagenomics. Frailty was associated with altered microbial composition, metabolic functions, and increased antimicrobial resistance, whereas non‐frail individuals showed healthier profiles.
Ana Barberá   +5 more
wiley   +1 more source

Medicago Sativa L. Saponin‐Driven Lactobacillus Intestinalis Restores Intestinal Stemness in Naturally Aged Mice via the Bile Acid‐FXR‐Wnt Signaling Axis

open access: yesAdvanced Science, Volume 13, Issue 4, 19 January 2026.
This study examines the mechanism by which alfalfa saponin (AS) regulates intestinal stemness via modulation of the gut microbiota. The results indicate that AS significantly increases the abundance of Lactobacillus intestinalis, which subsequently activates Wnt signaling via bile acid metabolism and enhances intestinal stemness. These findings provide
Mengqi Liu   +8 more
wiley   +1 more source

The microbiota–gut–brain axis in mild cognitive impairment and Alzheimer's disease: a scoping review of human studies

open access: yesAlzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract Alzheimer's disease (AD) is projected to become the highest‐burden neurological disorder globally. Mounting evidence implicates the gut microbiome in AD pathogenesis. This scoping review of gut microbiomes in mild cognitive impairment (MCI) and AD included dietary and probiotic interventions.
Alison Warren   +10 more
wiley   +1 more source

Baseline multi‐omics signatures could predict therapeutic response to neoadjuvant anti‐PD‐1 immunochemotherapy in non‐small‐cell lung cancer

open access: yesClinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Overview of study design. Metagenomic and plasma/fecal metabolomic studies were performed in 44 NSCLC patients who underwent neoadjuvant tislelizumab therapy plus platinum ‐ based doublet chemotherapy. Abstract Background Neoadjuvant anti‐programmed cell death 1 (PD‐1) immunochemotherapy has shown promising efficiency in the treatment of early‐stage ...
Ailing Cao   +11 more
wiley   +1 more source

Almond Polysaccharide Ameliorates DSS‐Induced Ulcerative Colitis in Mice by Restoring Intestinal Barrier Function and Modulating Gut Microbiota and SCFAs Metabolism

open access: yesFood Frontiers, Volume 7, Issue 1, January 2026.
This study shows that almond polysaccharide AP1 relieves DSS‐induced UC in mice by restoring the mucosal barrier, suppressing inflammation, and modulating gut microbiota and SCFA metabolism. ABSTRACT The development of new therapeutic strategies for ulcerative colitis (UC) requires the targeting of multiple pathogenic factors, including disruption of ...
Yanqi Peng   +7 more
wiley   +1 more source

Therapeutic Potential of Irpex lacteus Polysaccharides in Lupus Nephritis: Insights From Gut Microbiota and Metabolomics Analysis in MRL/Lpr Mice

open access: yesFood Science &Nutrition, Volume 14, Issue 1, January 2026.
Polysaccharides from Irpex lacteus alleviated kidney inflammatory response. PCP could reverse the phenotype of MRL/lpr mice, reduce autoantibody levels, alleviate inflammatory responses, and improve renal function. Improving the body's metabolism by gut microbes may be the possible mechanism of PCP in treating LN.
Guoxin Ji   +9 more
wiley   +1 more source

Comparative analysis of Faecalibacterium prausnitzii genomes shows a high level of genome plasticity and warrants separation into new species-level taxa

open access: yesBMC Genomics, 2018
Background Faecalibacterium prausnitzii is a ubiquitous member of the human gut microbiome, constituting up to 15% of the total bacteria in the human gut. Substantial evidence connects decreased levels of F.
Cormac Brian Fitzgerald   +6 more
doaj   +1 more source

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