Results 121 to 130 of about 1,276,965 (308)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Challenges for German Development Cooperation in the Run-up to the Millennium +5 Summit [PDF]
Extreme poverty blights the lives of one fifth of the world's population and denies more than 100 million children per year the chance of an education.
Kevin Watkins, Tilman Brück
core
The Transition to...Open Access [PDF]
, 2013 This report describes and draws conclusions from the transition of the Association for Learning Technology’s journal Research in Learning Technology from toll-access to Open Access, and from being published by one of the "big five" commercial publishers ...
Schmoller, Seb
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Determination of car run up – braking and manoeuvring parameters in an emergency situation in the case of limited road segment [PDF]
Transport, 2005 As the traffic intensity on roads increases, the number of road accidents also increases and the situations become more and more complicated. The presented method of reconstruction of preaccidental situations with the purpose of examination of road ...
O. Lukoševičienė, R. Pečeliūnas
doaj
Non-linear shallow water models for coastal run-up simulations [PDF]
, 2013 Shallow water models are frequently used to simulate ocean or coastal circulation or tsunami wave propagation. But these models are seldom used to explicitely reproduce for example tsunami wave run-up into coast.
Castro-Diaz, Manuel Jesus +2 more
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Sharia and Egypt’s constitution: an Iraqi blueprint [PDF]
, 2011 The constitutional debates that took place in the run-up to the formation of the current Iraqi constitution provide a blueprint for the questions Islamic parties must address if they are to be insiders to the process of consolidating ...
Banai, Ayelet
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source