Results 131 to 140 of about 1,276,965 (308)
Impact of an asteroid or comet in the ocean and extinction of terrestrial life [PDF]
, 1983 Finite difference calculations describing the impact mechanics associated with a 10 to 30 km diameter silicate or water object impacting a 5 km deep ocean overlying a silicate solid planet demonstrate that from 12 to 15% of the bolide energy resides in ...
Ahrens, T. J., Okeefe, J. D.
core +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Forecasting resilience profiles of the run-up to regime shifts in nearly-one-dimensional systems. [PDF]
J R Soc Interface, 2020 Adamson MW +3 more
europepmc +1 more source
Eos, 2017 Not all waves are created equal when it comes to eroding sandy shorelines. Here’s a look at the physics that drives the big ones.
openaire +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Biomechanics of Volleyball Players' Run-Up and Take-Off Link under Deep Learning.
Comput Intell Neurosci, 2022 Hu L, Liu L, Zhao K.
europepmc +1 more source
The effect of the run-up in the stock market on labor supply [PDF]
This article presents estimates of the effect of the run-up in the stock market on labor supply. The authors find that, in the absence of a run-up in the stock market, aggregate labor force participation rates would have been about 1 percent higher than ...
Eric French, Ing-Haw Cheng
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source