Results 51 to 60 of about 58,059 (245)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Effect of age and performance on pacing of marathon runners [PDF]

, 2017
Pantelis Theodoros Nikolaidis,1 Beat Knechtle2,3 1Exercise Physiology Laboratory, Attiki, Greece; 2Gesundheitszentrum St. Gallen, St. Gallen, 3Institute of Primary Care, University of Zurich, Zurich, Switzerland Abstract: Pacing strategies in marathon ...
Knechtle B, Knechtle, Beat; https://orcid.org/, Nikolaidis, Pantelis Theodoros; https://orcid.org/, Pantelis Theodoros Nikolaidis, Nikolaidis PT, Beat Knechtle   +5 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Change of indexes the special physical training of athletes-sprinters with the use of the author program of application Omega-3. [PDF]

Pedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2012
Research of the special physical qualities of 22 highly skilled athletes-sprinters is conducted in a competition period. In the training process of macrocycle the use of the author program of application is offered Omega-3.
Onishchuk S.V.
doaj  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Validity of a squash-specific fitness test [PDF]

, 2009
Purpose: This study examined the validity of a squash-specific test designed to assess endurance capability and aerobic power. Methods: Eight squash players and eight runners performed, in a counterbalanced order, incremental treadmill (TT) and squash ...
Wilkinson, Mick, Leedale-Brown, Damon, Leedale-Brown, D., Wilkinson, M., Winter, Edward, Winter, E.   +5 more
core  

Comparison of Two International Marathons in a Context of Sport Tourism

Sport i Turystyka, 2019
W obecnych czasach ludzkiego braku aktywności bieganie staje sie idealnym środkiem kompensacyjnym, który działa zapobiegawczo w stosunku do chorób cywilizacyjnych, które są w pewnym stopniu spowodowane brakiem aktywności fizycznej.
Milena Švedová, Ivan Uher, Tünde Dzurov-Vargová   +2 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Why Do We Run in a Sporting Event? A Gender Perspective through the Half-Marathon of Cordoba, Spain

Social Sciences
The study of participants’ motivations in sporting events is a recurring topic that provides valuable information for stakeholders interested in the event’s success. This motivation structure varies between geographies and evolves, so addressing new case
Jose E. Ramos-Ruiz, Miguel A. Solano-Sanchez, Lucia Castaño-Prieto, Lucia Garcia-Garcia   +3 more
doaj   +1 more source