Results 91 to 100 of about 4,292,819 (347)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Special endurance coefficients enable the evaluation of running performance
Scientific ReportsRunning performance from sprint to long distance is largely determined by the interplay between basic speed and endurance. Existing power-law, physiological, and theoretical models describe and explain the characteristic decline in pace with increasing ...
Wolfgang Blödorn, Frank Döring
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Recreational road runners: injuries, training, demographics and physical characteristics
Revista Brasileira de Cineantropometria e Desempenho Humano, 2008 http://dx.doi.org/10.5007/1980-0037.2008v10n3p277 The purpose of this study was to study recreational road runners in order to identify: their physical characteristics, demographics, running profile (training distance, frequency, duration, and ...
Joris Pazin +3 more
doaj +1 more source
International Journal of Environmental Research and Public Health, 2017 In Western countries, the popularity of running events has increased exponentially during the last three decades. However, little is known about the profile of non-participants.
D. van Dyck +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Applied SciencesThe aim of the current investigation was to examine the locomotor performance profile of elite ladies Gaelic football (LGF) players in relation to playing position and quarters of play.
Shane Malone +5 more
doaj +1 more source
Response of Gut Microbiota to Metabolite Changes Induced by Endurance Exercise
Frontiers in Microbiology, 2018 A few animal studies have shown that wheel running could reverse an unhealthy status by shifting the gut microbial composition, but no investigations have studied the effect of endurance running, such as marathon running, on human gut microbial ...
Xia Zhao +5 more
doaj +1 more source