Results 41 to 50 of about 172,573 (260)

Wheel Wear Predictions and Analyses of High-Speed Trains

Nonlinear Engineering, 2012
Wear of wheel profiles is one of the most critical issues affecting cost and performance of railway transportation systems. By altering the profile from the shape originally chosen by the designer, wear has a very large effect on vehicle dynamics, so ...
Jin X. C., Ahmadian
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Sleep Matters: Profiling Sleep Patterns to Predict Sports Injuries in Recreational Runners

Applied Sciences
Running is one of the most popular recreational sports worldwide, yet it carries a high risk of sports injuries. While various risk factors have been identified, sleep has emerged as a potentially important but understudied contributor in recreational ...
Jan de Jonge, Toon W. Taris
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Bouts of exercise elicit discordant testosterone: cortisol ratios in runners and non-runners

Archives of Endocrinology and Metabolism, 2018
Objective: The testosterone:cortisol ratio (T:C) is suggested to be used in order to examine whether physical exercise generates either a “catabolic environment” or an “anabolic environment”.
Thiago Paes de Barros De Luccia, José Eduardo Soubhia Natali, Alexandre Moreira, José Guilherme Chaui-Berlinck, José Eduardo Pereira Wilken Bicudo   +4 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Traceable Calibration Method for Online Measurement System of Train Wheelset Profile Based on Neural Network

机车电传动, 2019
As one of the basic equipment for rail transit operation and maintenance in China, the online measurement system of train wheelset mainly measures the running state of train running parts, including wheelset profile, tread abrasion and axle temperature ...
Enquan FANG, Jie QIN, Lili GENG
doaj  

Reducing the energy cost of running using a lightweight, low-profile elastic exosuit

Journal of NeuroEngineering and Rehabilitation, 2021
Background Human beings can enhance their distance running performance with the help of assistive devices. Although several such devices are available, they are heavy and bulky, which limits their use in everyday activities. In this study, we developed a
Jaeha Yang, Junil Park, Jihun Kim, Sungjin Park, Giuk Lee   +4 more
doaj   +1 more source