Results 21 to 30 of about 102,444 (132)

A Likelihood Ratio Approach for Utilizing Case‐Control Data in the Clinical Classification of Rare Sequence Variants: Application to BRCA1 and BRCA2

open access: yesHuman Mutation, Volume 2023, Issue 1, 2023., 2023
A large number of variants identified through clinical genetic testing in disease susceptibility genes are of uncertain significance (VUS). Following the recommendations of the American College of Medical Genetics and Genomics (ACMG) and Association for Molecular Pathology (AMP), the frequency in case‐control datasets (PS4 criterion) can inform their ...
Maria Zanti   +126 more
wiley   +1 more source

Investigating Adsorption of Cellulose Nanocrystals at Air–Liquid and Solid–Liquid Interfaces in the Presence of Hydrotropes

open access: yesAdvanced Materials Interfaces, Volume 9, Issue 31, November 3, 2022., 2022
Small molecules called hydrotropes were shown to be able to facilitate the coating of nanoparticles onto surfaces, replacing surfactant molecules more typically used. Being much smaller, hydrotropes cause nanoparticles to deposit via a different mechanism, allowing for a deeper understanding and finer control of nanoparticle coatings and influencing ...
Geosmin A. Turpin   +9 more
wiley   +1 more source

Maternal and neonatal outcomes after caesarean delivery in the African Surgical Outcomes Study: a 7-day prospective observational cohort study

open access: yesThe Lancet Global Health, 2019
Summary: Background: Maternal and neonatal mortality is high in Africa, but few large, prospective studies have been done to investigate the risk factors associated with these poor maternal and neonatal outcomes.
David Bishop, PhD   +1092 more
doaj   +1 more source

Comparative transcriptome reprogramming in oak galls containing asexual or sexual generations of gall wasps

open access: yesbioRxiv
Oak gall wasps have evolved strategies to manipulate the developmental pathways of their host to induce gall formation. This provides shelter and nutrients for the developing larva.
Eleanor Bellows   +5 more
semanticscholar   +1 more source

Will Organization Design Be Affected By Big Data

open access: yes, 2014
Computing power and analytical methods allow us to create, collate, and analyze more data than ever before. When datasets are unusually large in volume, velocity, and variety, they are referred to as “big data.” Some observers have suggested that in ...
Giles Slinger, Rupert Morrison
semanticscholar   +1 more source

Epigenetic Markers of Cell Division and Ageing in Relation to Breast Cancer Survival

open access: yesInternational Journal of Cancer, EarlyView.
ABSTRACT Breast cancer remains a major challenge to public health. Biomarkers may be useful to improve prediction of breast cancer survival. Several epigenetic markers of cell division and ageing based on DNA methylation have been proposed. In this study, we measured these epigenetic markers in breast tumours and assessed their prognostic value.
Luca Li   +10 more
wiley   +1 more source

Open letter: The need for a site‐based biodiversity standard measuring and certifying impacts from nature‐based projects

open access: yesPLANTS, PEOPLE, PLANET, EarlyView.
Despite growing investment in restoration, weak accountability and poor biodiversity monitoring mean many projects fail to achieve ecological recovery. The Global Biodiversity Standard (TGBS) offers a practical way to ensure that restoration finance delivers measurable gains for nature.
David Bartholomew   +254 more
wiley   +1 more source

Reading Dürer in Late Sixteenth‐Century Padua: Matteo Macigni (ca. 1510–1582), His Library and the Annotated Institutionum geometricarum (Paris, 1535)

open access: yesRenaissance Studies, EarlyView.
ABSTRACT This article contributes to the history of material culture and intellectual biography by definitively identifying the Paduan scholar Matteo Macigni (ca. 1510–1582) as the author of the annotations found in a 1535 copy of Albrecht Dürer’s Institutionum geometricarum currently preserved in Vicenza.
Laura Moretti
wiley   +1 more source

Patient‐reported outcomes, postoperative pain and pain relief after day‐case surgery (POPPY): short‐term peri‐operative analgesic use

open access: yesAnaesthesia, Volume 81, Issue 8, Page 1057-1067, August 2026.
Summary Introduction An increasing proportion of complex surgical procedures are being performed in the UK as day‐cases, with variable and limited follow up. Discharge prescriptions must provide adequate analgesia, while considering the safety of the patient and public, following best practice guidance and good opioid stewardship.
Anna Ratcliffe   +2083 more
wiley   +1 more source

Toward Harmonizing Quantification of Dopamine Neuron Imaging Biomarkers in Parkinson's Disease: The Centamine Scale

open access: yesAnnals of Neurology, Volume 99, Issue 4, Page 949-963, April 2026.
Objective Dopaminergic imaging is a key biomarker for both the investigation of the biology of Parkinson's disease and related synucleinopathies and the evaluation of potential therapies in clinical trials. This work presents a harmonized approach for quantifying dopaminergic molecular imaging tracers, such as [123I]ioflupane (dopamine transporter scan
Zhen Fan   +174 more
wiley   +1 more source

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