Results 61 to 70 of about 207,582 (294)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Thermocapillary effects in driven dewetting and self-assembly of pulsed laser-irradiated metallic films [PDF]

, 2009
In this paper the lubrication-type dynamical model is developed of a molten, pulsed laser-irradiated metallic film. The heat transfer problem that incorporates the absorbed heat from a single beam or interfering beams is solved analytically.
A. Atena, F. B. Wyart, I. W. Boyd, M. Khenner   +3 more
core   +5 more sources

The Influence of Fault Geometrical Complexity on Surface Rupture Length

Geophysical Research Letters
Propagating earthquakes must overcome geometrical complexity on fault networks to grow into large, surface rupturing events. We map step‐overs, bends, gaps, splays, and strands of length scales ∼100–500 m from the surface ruptures of 31 strike‐slip ...
A. M. Rodriguez Padilla, M. E. Oskin, E. E. Brodsky, K. Dascher‐Cousineau, V. Herrera, S. White   +5 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Polymer chain scission at constant tension - an example of force-induced collective behaviour

, 2011
The breakage of a polymer chain of segments, coupled by anharmonic bonds with applied constant external tensile force is studied by means of Molecular Dynamics simulation.
Milchev, A., Paturej, J., Rostiashvili, V. G., Vilgis, T. A.   +3 more
core   +1 more source

Rupture Dynamics of the 2025 Mw 7.7 Myanmar Earthquake: A Bilateral Supershear Rupture on Unusually Long Fault Superhighway

Geophysical Research Letters
The 2025 Mw 7.7 Myanmar earthquake ruptured the central Sagaing fault, a previously identified seismic gap with high seismic potential. Here, we perform hundreds of 3D dynamic rupture simulations to investigate the rupture dynamics, constrained by near ...
Zhongqiu He, Zhenguo Zhang, Xin Wang, Zijia Wang, T. C. Sunilkumar, Xiaohua Xu, Rui Wang   +6 more
doaj   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Analysis of Stress in the Cohesive Zone, Dissipation and Fracture Energy During Shear Rupture Experiments

Geophysical Research Letters
We analyze high resolution slip rate data obtained during dynamic shear rupture experiments by Berman et al. (2020), https://doi.org/10.1103/physrevlett.125.125503. We use an inverse method to extract the details of strength evolution within the cohesive
Nicolas Brantut
doaj   +1 more source

Dynamic Rupture Process of the 2023 Mw 7.8 Kahramanmaraş Earthquake (SE Türkiye): Variable Rupture Speed and Implications for Seismic Hazard

Geophysical Research Letters, 2023
We considered various non‐uniformities such as branch faults, rotation of stress field directions, and changes in tectonic environments to simulate the dynamic rupture process of the 6 February 2023 Mw 7.8 Kahramanmaraş earthquake in SE Türkiye.
Zijia Wang, Wenqiang Zhang, Tuncay Taymaz, Zhongqiu He, Tianhong Xu, Zhenguo Zhang   +5 more
doaj   +1 more source