Clinical heterogeneity in vitiligo: Identification of clinical markers based patient clusters
Journal of the European Academy of Dermatology and Venereology, EarlyView.Vitiligo is a chronic autoimmune disease with heterogeneous clinical presentations. This study analysed 399 patients using hierarchical clustering and identified five phenotypes based on clinical characteristics and lesion distribution. Two groups exhibited high disease activity and extensive involvement.
Laura Galissi +8 more
wiley +1 more source
The role of Janus kinase signaling in graft-versus-host disease and graft versus leukemia [PDF]
, 2018 Choi, Jaebok +3 more
core +2 more sources
A phase II trial of ruxolitinib in combination with azacytidine in myelodysplastic syndrome/myeloproliferative neoplasms [PDF]
, 2017 Rita Assi +22 more
openalex +1 more source
Analysis of predictors of response to ruxolitinib in patients with myelofibrosis in the phase 3b expanded-access JUMP study [PDF]
, 2020 Vikas Gupta +13 more
openalex +1 more source
Therapeutic advances in pruritus as a model of personalized medicine
Journal of the European Academy of Dermatology and Venereology, EarlyView.Recent advances in itch biology reveal that chronic pruritus arises from distinct neuroimmune pathways driven by cytokines, JAK, BTK and GPCRs. Targeted biologics and small molecule inhibitors such as dupilumab, nemolizumab, remibrutinib and JAK inhibitors precisely modulate these pathways, leading to a new era of personalized therapeutics in pruritus.
Kelsey Auyeung +2 more
wiley +1 more source
The JAK1/JAK2‐ inhibitor ruxolitinib inhibits mast cell degranulation and cytokine release [PDF]
, 2018 Maud A.W. Hermans +6 more
openalex +1 more source
Fatal Chronic Varicella‐Zoster Viral Infection in a Young Man With Chediak–Higashi Syndrome
Pediatric Dermatology, EarlyView.ABSTRACT Chediak–Higashi syndrome (CHS) is a rare autosomal recessive primary immunodeficiency characterized by partial oculocutaneous albinism, neurologic involvement, and a predisposition to severe infections. Patients are particularly susceptible to developing hemophagocytic lymphohistiocytosis (HLH), which significantly worsens prognosis. We report
Albane Badet +4 more
wiley +1 more source
Sex-Specific Protection of Endothelial Function after Vascular Ischemia/Reperfusion Injury by the Senomorphic Agent Ruxolitinib [PDF]
, 2023 Lars Saemann +5 more
openalex +1 more source