Results 171 to 180 of about 29,580 (292)

Extracorporeal Photopheresis for Chronic Graft‐Versus‐Host Disease According to 2014 NIH Consensus Criteria

Journal of Clinical Apheresis, Volume 40, Issue 6, December 2025.
ABSTRACT Chronic graft‐versus‐host disease (cGVHD) remains a major cause of morbidity and mortality following allogeneic hematopoietic stem cell transplantation. Many cGVHD patients require prolonged systemic immunosuppression with corticosteroids, which carry significant adverse effects, and alternative therapies are often required.
Yitzhar Goretsky, Noa Holtzman, Sunwoo Han, Isildinha M. Reis, Vera Suzuki, Pepita Jean, Karla Mones, Meilin Diaz‐Paez, Cara Benjamin, Amer Beitinjaneh, Mark Goodman, Antonio Jimenez Jimenez, Lazaros Lekakis, Denise Pereira, Jay Spiegel, Yanyun Wu, Damian J. Green, Krishna V. Komanduri, Trent P. Wang   +18 more
wiley   +1 more source

Targeted Therapy for Idiopathic Inflammatory Myopathy

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of autoimmune disorders characterized by chronic muscle inflammation and significant extramuscular involvement. A substantial proportion of patients exhibit refractory or relapsing disease despite conventional immunosuppressive therapies, necessitating the ...
Ruijie Wang, Wei Lin, Qibing Xie, Geng Yin   +3 more
wiley   +1 more source

Ruxolitinib plus steroids for acute graft versus host disease: a multicenter, randomized, phase 3 trial

Liping Dou, Yanli Zhao, Jingjing Yang, Lei Deng, Nan Wang, Xiawei Zhang, Qingyang Liu, Yang Yan, Zhijie Wei, Fuxu Wang, Yifan Jiao, Fei Li, Songhua Luan, Liangding Hu, Sujun Gao, Chuanfang Liu, Xiangjun Liu, Jinsong Yan, Xuejun Zhang, Fang Zhou, Peihua Lu, Dai‐Hong Liu   +21 more
openalex   +1 more source

[Regulation of Ruxolitinib on matrix metalloproteinase in JAK2V617F positive myeloroliferative neoplasms cells].

, 2017
Gaigai Liu, L J Zhang, Jiayao Fu, W T Liang, Zhen Cheng, Peide Bai, Yaoyao Bian, Jie Wan   +7 more
openalex   +2 more sources

Clinical and Immunological Impact of JAK Inhibition in Concurrent Down Syndrome and STAT1 Gain of Function. [PDF]

J Clin Immunol
Blanco-Lobo P, Gilabert-Prieto P, de Felipe B, Moreno-Fuentes D, Guisado Hernández P, Ortiz-Ramírez A, Mensa-Vilaró A, Aróstegui JI, Palmou N, Velasco Gonzalez V, Deyà Martinez Á, Ramakers J, Ivorra-Cortés J, Roca C, Cordero E, Guillen I, Valerdiz Menéndez N, Lucena JM, Gaboli M, Olbrich P, Neth O.   +20 more
europepmc   +1 more source

Adult Acute Myeloid Leukaemia With DDX3X::MLLT10: A Rare Entity With Significant Unmet Clinical Needs

eJHaem, Volume 6, Issue 6, December 2025.
ABSTRACT DDX3X::MLLT10¸ which arises from t(X;10)(p11.4;p12.31), is infrequently observed in adult acute myeloid leukaemia (AML). The clinical and pathological characteristics are also not well characterised, detailed in only two cases published to date. This third case reports the fusion gene in a 27‐year‐old female with acute myelomonocytic leukaemia
Jun Yen Ng, Arun SR, Maansi Joshi, Dipti Talaulikar   +3 more
wiley   +1 more source

Duloxetine, an SNRI, Targets pSTAT3 Signaling: <i>In</i>-Silico, RNA-Seq and <i>In</i>-Vitro Evidence for a Pleiotropic Mechanism of Pain Relief. [PDF]

Int J Mol Sci
Abdi SAH, Azhar G, Zhang X, Wei JY.
europepmc   +1 more source

Clinical Images: Periumbilical wound dehiscence and pathergy in a neonate with OTULIN‐related autoinflammatory syndrome

ACR Open Rheumatology, Volume 7, Issue 12, December 2025.
Hiu Laam Christy Sit, Paul E. Gray, Sophia Davidson, Carolyn Russell, Seth L. Masters   +4 more
wiley   +1 more source

Effect of ruxolitinib on the oral mucosa in steroid-refractory graft-versus-host disease: a prospective observational exploratory study. [PDF]

Clin Oral Investig
Bellido M, Jonk AE, Kaurinovic M, Biswana A, Hazenberg CLE, Choi G, Choi G, Morsink LM, Huls G, Vissink A, Delli K.   +10 more
europepmc   +1 more source

Case Report of a Patient With Psoriasis Vulgaris, Psoriatic Arthritis and Alopecia Universalis Successfully Treated With Tofacitinib and Methotrexate

JEADV Clinical Practice, Volume 4, Issue 5, Page 1182-1185, December 2025.
Capsule Summary We present a case of a 31‐year‐old female with alopecia universalis, psoriasis vulgaris, and psoriatic arthritis, who showed poor response to prior treatments. Following the initiation of a combination therapy with tofacitinib and methotrexate, significant improvements in joint pain and hair regrowth were observed. This case underscores
Jan Nicolai Wagner, Matthias Augustin, Caroline Gewiss, Carolin Grote, Nesrine Ben‐Anaya   +4 more
wiley   +1 more source