Results 191 to 200 of about 29,580 (292)

Tumor Cell Plasticity in Cancer: Signaling Pathways and Pharmaceutical Interventions

MedComm, Volume 6, Issue 12, December 2025.
Cell plasticity refers to a dynamic program through which cells reprogram their phenotype, acquiring new histologic and molecular characteristics. Recognized as a hallmark of cancer, cellular plasticity plays a critical role in tumor evolution.
Shangwei Sun, Yunwei Sun, Ling Lan, Siyuan Luan, Jin Zhou, Jiehui Deng, Yong Yuan, Zhong Wu   +7 more
wiley   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, Volume 1, Issue 3, Page 322-358, December 2025.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Ruxolitinib as first‐line treatment in secondary hemophagocytic lymphohistiocytosis: A single patient experience [PDF]

, 2017
Jessica Slostad, Patrick Hoversten, Candace L. Haddox, Kamila I. Cisak, Jonas Paludo, Ayalew Tefferi   +5 more
openalex   +1 more source

Resolution of secondary hemophagocytic lymphohistiocytosis after treatment with the JAK1/2 inhibitor ruxolitinib [PDF]

, 2019
DiPersio, John F., Goldsmith, Scott R., Saif Ur Rehman, Sana, Shirai, Cara L., Vij, Kiran   +4 more
core   +1 more source

Successful Neutrophil Engraftment with Continued Ruxolitinib in Cord Blood Transplantation. [PDF]

Blood Cell Ther
Nagano T, Kondo T, Hiyama R, Ikeda D, Hayashino K, Inoue Y, Ueno M, Ueda Y, Kubota S, Kobayashi H, Seike K, Fujiwara H, Asada N, Ennishi D, Fujii K, Fujii N, Matsuoka KI, Maeda Y.   +17 more
europepmc   +1 more source

Recent Synthetic Advances in C–H/N–H Functionalization of 1H‐Pyrazoles: Diverse Strategies Across Variously Substituted Scaffolds

The Chemical Record, Volume 25, Issue 12, December 2025.
Systematic overview of pyrazole functionalization reactions from C‐5 to N−H. It covers different strategies, from traditional cross‐coupling of prefunctionalized pyrazoles to more efficient direct functionalizations. This review briefly and systematically overviews C–H and N–H functionalization reactions of pyrazoles, aimed at creating new CC and C ...
Karolina Dzedulionytė Müldür, Asta Žukauskaitė, Algirdas Šačkus, Eglė Arbačiauskienė   +3 more
wiley   +1 more source

The impact of JAK2V617F variant allele frequency in MPN patients following PEGylated interferon alpha discontinuation

British Journal of Haematology, Volume 207, Issue 6, Page 2597-2601, December 2025.
Treatment with pegylated interferon α resulted in a molecular response in 91% of patients with an average decrease in JAK2V61F VAF of 48.5% from baseline. In patients that discontinued treatment, the JAK2V617F VAF at the time of treatment discontinuation was the best indicator of durable remission over the 6‐month follow‐up period.
Ryan Brown, Rebekah Bennett, Clare Crean, Andrew Hindley, Julie McGimpsey, Nicholas Cunningham, Aaron Niblock, Suzanne McPherson, Kathryn Boyd, Allister Foy, Ciaren Graham, Graeme Greenfield, Mary Frances McMullin, Mark A. Catherwood   +13 more
wiley   +1 more source

JAK Inhibition in STAT1 Gain-of-Function-Associated Histoplasmosis and HLH. [PDF]

J Clin Immunol
Patel J, Daniels E, Hawley E, Consortium W, Kitcharoensakkul M.   +4 more
europepmc   +1 more source

Enhanced Mitochondrial Priming By Momelotinib Confers Superior In Vivo Efficacy in Combination with Venetoclax Compared to Gilteritinib or Ruxolitinib [PDF]

Zachary Kincaid, Sekhu Ansari, Mohammad Azhar, Meenu Kesarwani, Mohammad Azam   +4 more
openalex   +1 more source

Heterogeneity of Cellular Senescence: Subtype‐Specific Mechanisms and the Emerging Role of Plasma Membrane Damage

Cancer Science, Volume 116, Issue 12, Page 3274-3285, December 2025.
Just as the term “cancer cell” encompasses a wide spectrum of cells, the term “senescent cell” should also be regarded as an umbrella term that includes cells with heterogeneous molecular profiles. In this review, we provide an updated overview of the molecular mechanisms underlying distinct senescent cell subtypes induced by various stimuli, including
Enaam Alghamdi, Keiko Kono
wiley   +1 more source