Results 141 to 150 of about 2,517 (166)
Some of the next articles are maybe not open access.
Pathogenesis of Rift Valley fever virus (RVFV) in inbred rats
Microbial Pathogenesis, 1987The pathogenesis of Rift Valley fever in adult rats from 3 inbred strains (LEW, MAXX, WF) was investigated. WF rats all died by day 2 postinoculation with viral tissue titers reaching 9 log10 PFU/g. LEW and MAXX rats were resistant to liver disease, but fatal necrotising encephalitis developed in 16 and 44% of the rats, respectively. Detection of serum
G W, Anderson, T W, Slone, C J, Peters
openaire +2 more sources
A glycerophospholipid-specific pocket in the RVFV class II fusion protein drives target membrane insertion [PDF]
Science, 2017 Unmasking class II membrane fusion Rift Valley fever virus (RVFV) is transmitted by mosquitos and enters cells through receptormediated endocytosis. The infection process requires class II membrane fusion proteins, which insert a hydrophobic fusion loop into cell membranes and then refold. Guardado-Calvo et al.
Scott Jeffers +2 more
exaly +7 more sources
PLoS ONE, 2011 Rift Valley fever (RVF) is a zoonotic disease caused by Rift Valley fever virus (RVFV). RVFV is a category A pathogen that belongs to the genus Phlebovirus, family Bunyaviridae. Understanding early host events to an infectious exposure to RVFV will be of significant use in the development of effective therapeutics that not only control pathogen ...
Kylene Kehn-Hall +2 more
exaly +5 more sources
Virology, 2014 Rift Valley fever virus (RVFV) infection is often associated with pronounced liver damage. Previously, our studies revealed altered host phospho-signaling responses (NFκB, MAPK and DNA damage responses) in RVFV infected epithelial cells that correlated with a cellular stress response.
Lance A Liotta +2 more
exaly +3 more sources
Emerging Microbes and InfectionsRift Valley fever virus (RVFV) is a Phlebovirus causing febrile and haemorrhagic illness in ruminants and humans. The viral protein NSs is a major virulence factor that suppresses the IFN-β response in various hosts. Hence, RVFV variants lacking functional NSs, such as Clone 13, are highly attenuated.
Paul Wichgers Schreur +2 more
exaly +3 more sources
Vector Competence Assays for RVFV in Mosquitoes
Rift Valley fever virus (RVFV) is the causative agent of Rift Valley fever, a mosquito-borne zoonotic febrile illness that primarily affects ruminants, camels, and humans. It is endemic in sub-Saharan Africa and the Arabian Peninsula, albeit with the potential to spread to and establish in non-endemic countries where mosquito vectors are present ...Lotty, Birnberg, Núria, Busquets
openaire +2 more sources
Development and Initial Evaluation of a SERS‐Based RVFV Assay
Journal of Raman SpectroscopyABSTRACT Rift Valley fever virus (RVFV), a WHO Blueprint Priority Pathogen, continues to cause major health and economic losses in endemic regions, yet current molecular and serological diagnostics remain inaccessible or insufficiently sensitive in many settings.
T. Domfe, N. Mhlanga, L. Sikhwivhilu
openaire +2 more sources
Yeast Expression and Activity Assay of RVFV Polymerase
Rift Valley fever (RVF) virus is widespread worldwide and poses a severe threat to human life and property. RVF viral polymerase plays a vital role in the replication and transcription of the virus. Here, we describe how to express and purify this polymerase and perform tests for its in vitro activity assays.Xue, Wang +3 more
openaire +2 more sources
Monitoring RVFV Infection Using Bioluminescent Reporter Viruses In Vivo
Rift Valley fever virus is able to infect multiple organs and cell types, and the course of infection varies between viral strains and between individuals in particular according to age, genetic background, and physiological status. Studies on viral and host factors involve detecting and quantifying viral load at multiple time points and in multiple ...Céline Gommet +2 more
openaire +2 more sources
Characterization of RVFV Nucleocapsid Protein Binding Sites on RNA by iCLIP-seq
The nucleocapsid protein (N) in Rift Valley fever virus is an RNA-binding protein that functions in viral transcription, replication, and packaging. In this chapter, the method for studying protein-RNA interactions in context of viral infection using individual nucleotide resolution, cross-linking, immunoprecipitation, and sequencing (iCLIP-seq) is ...Miyuki, Hayashi, J Stephen, Lodmell
openaire +2 more sources