Results 31 to 40 of about 284,044 (247)

La ségrégation spatiale selon Schelling : la perversité est ailleurs [PDF]

open access: yes, 2006
La modélisation de la ségrégation spatiale proposée dans les années 1970 par Thomas C. Schelling a marqué les esprits en raison de l’effet pervers qu’elle suggérait : une forte ségrégation pourrait être le résultat collectif de décisions individuelles ...
Forse, Michel, Parodi, Maxime
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Ségrégation socio-spatiale et ethnicisation des territoires scolaires à Marseille

open access: yesBelgeo, 2017
In France, social mixing is one of the main objectives of school policies. The French school mapping system tends to reproduce urban socio-spatial segregation at school.
Gwenaëlle Audren, Virginie Baby-Collin
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Les défis structurels, organisationnels et cognitifs liés à la gestion de l’hétéropgénéité des élèves dans les systèmes éducatifs

open access: yesSchweizerische Zeitschrift für Bildungswissenschaften, 2018
Ce texte s’intéresse aux différentes voies d’identification et de traitement de la question de l’hétérogénéité des élèves dans les systèmes éducatifs. Il convoque des résultats de recherche bien établis faisant apparaître combien le regroupement d’élèves
Farah Dubois-Shaik, Vincent Dupriez
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

Desigualdades educacionais em contextos urbanos: um estudo da geografia de oportunidades educacionais na cidade do Rio de Janeiro

open access: yesEducação & Sociedade, 2013
O objetivo do trabalho é trazer uma contribuição teórica dos estudos da sociologia urbana, bem como a contribuição metodológica das análises espaciais (georreferenciamento), para analisar as desigualdades educacionais em grandes centros urbanos.
Mariane Campelo Koslinski   +2 more
doaj   +1 more source

Minority Segregation Processes in an Urban Context: a Comparison between Paris and Rome Recent trends in ethnic segregation in cities: Paris and Rome compared [PDF]

open access: yes, 2015
Il processo di segregazione delle minoranze etniche assume caratteristiche diverse nei paesi di antica immigrazione (Francia, Gran Bretagna, Paesi Bassi, Germania) rispetto a quanto osservato in quelli di nuovo accoglimento (Italia, Spagna, Grecia e ...
CASACCHIA, Oliviero   +2 more
core  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

La démocratie locale en quartiers à Paris : une ségrégation territoriale ?

open access: yesL'Espace Politique, 2010
The law on “local democracy” adopted in February 2002 imposes in Paris the creation of participative subdivisions within the territories of municipalities (arrondissements).
Anne-Lise Humain-Lamoure
doaj   +1 more source

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