Results 41 to 50 of about 284,044 (247)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Les cadres supérieurs et les professions intermédiaires dans l'espace urbain: des dynamiques résidentielles divergentes, entre séparatisme et mixité sous contrôle [PDF]

, 2011
En Île-de-France, la répartition des cadres dans l’espace urbain montre l’importance d’une distinction majeure : entre les « classes supérieures » (patrons, professions libérales et cadres d’entreprise) et les « classes moyennes-moyennes » (cadres du ...
Oberti, Marco, Préteceille, Edmond
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Building Inequality: Housing Segregation and Income Segregation

Sociological Science, 2019
This article foregrounds housing in the study of residential segregation. The spatial configuration of housing determines the housing opportunities in each neighborhood, the backdrop against which households' resources, preferences, and constraints play ...
Ann Owens
doaj   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Ségrégation socio-spatiale et foncier ferroviaire à Yaoundé : cas du LIEU-DIT ELIG-EDZOA-RAILS [PDF]

Revue de Géographie Tropicale et d’Environnement
Avec le fort croît démographique qui se traduit par une croissance spatiale rapide, la ville de Yaoundé connaît ces dernières années une urbanisation spontanée et anarchique sans précédent. Outre les zones marécageuses et inondables, les bas-fonds, etc.,
Joseph-Eric NNOMENKO’O
doaj   +1 more source

Ségrégation, sélectivité et 'diversité' dans les lycées publics de Chicago et de Paris [PDF]

, 2011
Après plusieurs décennies de politiques de déségrégation raciale dans les écoles de la ville de Chicago, l’abandon formel en 2009 du critère racial comme principe majeur de discrimination positive s’est traduit par la mise en place d’un nouveau ...
Oberti, Marco
core   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Mobilités quotidiennes et ségrégation : le cas des adolescents de Zones Urbaines Sensibles franciliennes

Espace populations sociétés, 2009
In most of the previous studies on segregation, it is first and foremost considered to be the residential concentration of low income populations. In difference, this article is aimed at better documenting the daily mobility of residents of segregated ...
Nicolas Oppenchaim
doaj   +1 more source