Results 171 to 180 of about 136,566 (245)

Cidea Targeting Protects Cochlear Hair Cells and Hearing Function From Drug‐ and Noise‐Induced Damage

open access: yesAdvanced Science, Volume 13, Issue 7, 3 February 2026.
Acquired sensorineural hearing loss is primarily caused by the damage or loss of cochlear hair cells, induced by factors such as noise exposure and ototoxic drugs. The deficiency of apoptosis‐inducing gene Cidea in Cidea KO mice or by delivering CRISPR/SlugCas9‐HF via AAV to edit Cidea effectively alleviated hair cell damage and hearing loss caused by ...
Shasha Zhang   +14 more
wiley   +1 more source

APP‐mediated intracellular signaling rescues sleep impairment and blood–brain barrier leakage in Alzheimer's disease mouse model

open access: yesAlzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Amyloid beta peptide (Aβ) accumulation in the brain is an Alzheimer´s disease (AD) hallmark. Sleep disturbances hamper Aβ production and clearance, thereby exacerbating the Aβ burden. The mechanisms involved remain unclear. We reported that amyloid precursor protein (APP), the Aβ source, possesses intracellular signaling that ...
Clémentine Puech   +7 more
wiley   +1 more source

Concurrent Scrub Typhus, Dengue, and Leptospirosis: A Rare Triple Co‐Infection: A Case Report and Comprehensive Literature Review

open access: yesClinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT In endemic areas, acute undifferentiated febrile illness has a wide differential with overlapping features that can lead to misdiagnosis. Although triple co‐infection with scrub typhus, dengue, and leptospirosis is extremely rare, high clinical suspicion and early detection are vital to avoid delayed treatment, multi‐organ dysfunction, and ...
Sulav Kumar Jha   +5 more
wiley   +1 more source

Cardiotropic Gene Therapy for Heart Failure: Translational Lessons From AB‐1002

open access: yes
MedComm – Future Medicine, Volume 5, Issue 1, March 2026.
Nghia Phu Nguyen, Phillip Tran
wiley   +1 more source

Home - About - Disclaimer - Privacy