Results 161 to 170 of about 60,211 (294)

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

The Methyl Donor S-Adenosylmethionine Inhibits Active Demethylation of DNA [PDF]

, 2003
Nancy Detich, Stefan Hamm, George Just, J. David Knox, Moshe Szyf   +4 more
openalex   +1 more source

A growth‐based assay using fluorescent protein emission to screen for S‐adenosylmethionine synthetase inhibitors [PDF]

, 2023
Ronald E. Viola, Gwenn G. Parungao, Robert Blumenthal   +2 more
openalex   +1 more source

Substrate selectivity of human histidine methyltransferase METTL9

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Methylation of histidine residues in zinc transporters by histidine methyltransferase METTL9 plays an important role in modulating their metal‐binding properties. Here, we report synthetic, enzymatic, and computational studies on human METTL9‐catalyzed Nπ‐methylation of His375 in zinc transporter SLC39A5‐derived peptides in which the histidine
Sadaf Ahmad, Laust Moesgaard, Christian W. Tornøe, Paulina Emmel, Klaudia Slusarczyk, Jakub Drozak, Jacob Kongsted, Jasmin Mecinović   +7 more
wiley   +1 more source

Targeting PRMTs Creates Vulnerability of DNA Double‐Stand Break Repair Pathways, and Potentiates Chemotherapy Efficacy in TNBC

Cancer Science, Volume 117, Issue 5, Page 1273-1285, May 2026.
Our work makes the proof of concept that there is a clinical benefit to target both PRMT1 and PRMT5 to maximize the anti‐tumoral effect of chemotherapy in triple negative breast cancer. ABSTRACT Patients with triple‐negative breast cancer (ER−, PR−, and HER2−) are routinely treated with chemotherapies that induce DNA damage.
Charlène Thiebaut, Sébastien Martinez, Ludivine Pruvost, Louisane Eve, Rania El‐Botty, Laura Sourd, Elodie Montaudon, Ahmed Dahmani, Heloise Derrien, Stéphanie Sentis, Coralie Poulard, Elisabetta Marangoni, Olivier Trédan, Muriel Le Romancer   +13 more
wiley   +1 more source

Circulating Rhythmic Metabolites and Causal Risk of Type 2 Diabetes in Adults in the Canadian Longitudinal Study on Aging

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 4243-4252, May 2026.
ABSTRACT Aims Circadian regulation of metabolism is an important factor in metabolic health, yet the role of rhythmic metabolites in Type 2 diabetes development remains poorly understood. This study investigated associations between circulating rhythmic metabolites and incident Type 2 diabetes risk and evaluated causal relationships using two‐sample ...
Divya Joshi, Talha Rafiq, Marie Pigeyre, Renee de Mutsert, Femke Rutters, David J.T. Campbell, Jean‐Pierre Despres, Andre C. Carpentier, Joris Hoeks, Patrick Schrauwen, Parminder Raina   +10 more
wiley   +1 more source

Arsenic detoxification and evolution of trimethylarsine gas by a microbial arsenite S -adenosylmethionine methyltransferase

, 2006
Jie Qin, Barry P. Rosen, Yang Zhang, Gejiao Wang, Sylvia Franke, Christopher Rensing   +5 more
openalex   +1 more source

SAM-VI RNAs selectively bind S-adenosylmethionine and exhibit similarities to SAM-III riboswitches [PDF]

, 2017
Gayan Mirihana Arachchilage, Madeline E. Sherlock, Zasha Weinberg, Ronald R. Breaker   +3 more
openalex   +1 more source

Arabidopsis acclimation to daily environmental fluctuations converts a defense response regulator into a susceptibility factor toward Sclerotinia

New Phytologist, Volume 250, Issue 4, Page 2516-2534, May 2026.
Summary Acclimation enables plants to adjust to immediate environmental fluctuations and is therefore key to the resilience of plant disease resistance in a time of climate change. Here, we report on the acclimation of Arabidopsis thaliana quantitative immune responses against the fungal pathogen Sclerotinia sclerotiorum to daily environmental ...
Marie Didelon, Justine Sucher, Florent Delplace, Pedro Carvalho‐Silva, Matilda Zaffuto, Adelin Barbacci, Sylvain Raffaele   +6 more
wiley   +1 more source

Arsenic methylation by an arsenite S-adenosylmethionine methyltransferase from Spirulina platensis

, 2016
Yu-Qing Guo, Ximei Xue, Yu Yan, Yong‐Guan Zhu, Guidi Yang, Jun Ye   +5 more
openalex   +2 more sources