Results 151 to 160 of about 43,956,264 (204)

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, Volume 13, Issue 59, 23 October 2026.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Associations Between Circulating Metabolites and Skin Cancer: A Bidirectional Two‐Sample Mendelian Randomization Study

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Skin cancer is the most common type of cancer worldwide, categorized into melanoma and non‐melanoma types. While genetics play a crucial role in the development of skin cancer, recent developments in metabolomics have revealed that circulating metabolites influence genetic risk profiles.
Jiangfan Yu, Hongyan Gong, Zhuotong Zeng, Rong Xiao   +3 more
wiley   +1 more source

Coordinated TNF–NF‐κB and PI3K–Akt Modulation by Yueju Pill in Hashimoto's Thyroiditis: A Network Pharmacology and Molecular Docking Study

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Network pharmacology and molecular docking identify a coordinated dual‐axis regulatory framework for Yueju pill in Hashimoto's thyroiditis. Candidate compounds and prioritized targets converge on TNF–NF‐κB inflammatory and PI3K–Akt survival/apoptosis signaling, providing computational support for a testable multi‐target hypothesis requiring ...
Hao Zhang, Kuojun Ren, Shengying Wang
wiley   +1 more source

Shared Genetic Architecture Between Common Epilepsies and Subcortical Brain Volumes Is Associated With Cognition and Mental Health

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Epilepsy is a common neurological disorder, often presenting with psychiatric comorbidities and cognitive impairment. Neuroimaging studies have suggested associations between epilepsy and subcortical volumetric abnormalities. Here, we dissected the shared genetic architecture between common epilepsies and subcortical volumes.
Zesheng Li, Qian Wu, Yanfeng Yang, Jianwei Shi, Xuegang Niu, Yuanyuan Zhang, Yumin Luo, Cheng Wei, Yongzhi Shan, Feng Liu, Josemir W. Sander, Guoguang Zhao   +11 more
wiley   +1 more source

Functional Profiles of Fish Gut Microbiota Associated With Feeding Habits in the Midstream of the Jialing River Under Cascade Channelization

Ecology and Evolution, Volume 16, Issue 10, October 2026.
This study investigates how feeding habits shape the gut microbiota of fish inhabiting the channelized middle reaches of the Jialing River. Using 16S rRNA gene amplicon sequencing and PICRUSt2 analysis, we compared the gut microbial communities of carnivorous, omnivorous, and herbivorous fish.
Mengying Hu, Chang Chen, Yuan Feng, Liang Liu, Xiaopeng Tang, Heran Wang, Fubin Zhang   +6 more
wiley   +1 more source

Broken Engines of Immunity: Mitochondrial Dysfunction in T Cells Across Cancer and Complex Pathologies

European Journal of Immunology, Volume 56, Issue 10, October 2026.
Mitochondria not only play a fundamental role in energy production but also regulate physiological processes, including metabolism, homeostasis, and immune function. In T cells, they control activation, differentiation, and function. Their dysfunction contributes to immune exhaustion in cancer, chronic infections, and ageing. This review examines these
Carolina Brescia, Giuseppe Viglietto, Rosario Amato   +2 more
wiley   +1 more source

Conditional Associations Among Chronic Disease Indicators, Risk Behaviors, Health Habits, and Disability Indicators in an Analytic ENDES Sample of Peruvian Adults: A Secondary Analysis Using Exploratory Network Analysis, 2021–2023

Lifestyle Medicine, Volume 7, Issue 4, October 2026.
ABSTRACT Background Multidomain health indicators, including chronic disease indicators, risk behaviors, health habits, depressive symptomatology, disability indicators, and healthcare‐access indicators, may be interconnected through complex patterns of conditional association.
Miguel Basauri‐Delgado, Deysi Pedraza‐Ricra, Maryuri Natalia More‐Espinoza, Ruth Gabriela Yapo‐Esteban, Jacksaint Saintila   +4 more
wiley   +1 more source

1H HR‐MAS NMR Metabolomics in Combination With Transcriptomic Correlation Provides New Insights Into Metabolic Heterogeneity Across Breast Cancer Immunohistochemical Subtypes

NMR in Biomedicine, Volume 39, Issue 10, October 2026.
Metabolomic profiling of breast cancer tissue using 1H HR‐MAS NMR spectroscopy and LCModel‐based quantitative analysis revealed metabolite differences associated with immunohistochemical subtypes, and subsequent metabolomics–transcriptomics integration linked these subtype‐dependent metabolic signatures to pathways in choline metabolism, one‐carbon ...
Irene Garcia‐Bocanegra, Jesus David Urbano‐Gamez, Antonio Perez‐Cardona, Laura Barrios, Maria Isabel Somoza‐Ramírez, Luis Vicioso, Elena Pardo‐Susacasa, Gema Diaz‐Cordoba, Maria Mercedes Acebal‐Blanco, Francisco Sendra‐Portero, Maria Luisa Garcia‐Martin   +10 more
wiley   +1 more source

Dual Stabilization of S‑Adenosylmethionine for Enzymatic DNA Labeling

JACS Au
Jonas Bucevičius, Ru̅ta Gerasimaitė, Gražvydas Lukinavičius   +2 more
doaj   +1 more source

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, Volume 41, Issue 10, Page 1105-1118, October 2026.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source