Results 51 to 60 of about 1,831,541 (219)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Massless S-matrix bootstraps and RG flows
Journal of High Energy PhysicsWe find complete solutions of S-matrix bootstrap equations for the scatterings of massless particles in (1+1) dimensions with A n symmetries. We show that only three types (minimal, diagonal, and saturated cases) of these S-matrices can generate RG flows
Changrim Ahn
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Relative entropy in scattering and the S-matrix bootstrap
SciPost Physics, 2020 We consider entanglement measures in 2-2 scattering in quantum field theories, focusing on relative entropy which distinguishes two different density matrices.
Anjishnu Bose, Parthiv Haldar, Aninda Sinha, Pritish Sinha, Shaswat S Tiwari
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Reconstructing S-matrix Phases with Machine Learning
Journal of High Energy PhysicsAn important element of the S-matrix bootstrap program is the relationship between the modulus of an S-matrix element and its phase. Unitarity relates them by an integral equation.
Aurélien Dersy +2 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
On beautiful analytic structure of the S-matrix
New Journal of Physics, 2019 For an exponentially decaying potential, analytic structure of the s -wave S -matrix can be determined up to the slightest detail, including position of all its poles and their residues. Beautiful hidden structures can be revealed by its domain coloring.
Alexander Moroz, Andrey E Miroshnichenko
doaj +1 more source
The S-matrix bootstrap II: two dimensional amplitudes
Journal of High Energy Physics, 2017 We consider constraints on the S-matrix of any gapped, Lorentz invariant quantum field theory in 1 + 1 dimensions due to crossing symmetry and unitarity.
Miguel F. Paulos +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source