Results 51 to 60 of about 1,786,387 (265)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

S-matrix at spatial infinity

Physics Letters B, 2008
We provide a new method to construct the S-matrix in quantum field theory. This method implements crossing symmetry manifestly by erasing the a priori distinction between in- and out-states. It allows the description of processes where the interaction weakens with distance in space, but remains strong in the center at all times.
Colosi, Daniele, Oeckl, Robert
openaire   +2 more sources

Polarization-Free Generators and the S-Matrix [PDF]

Communications in Mathematical Physics, 2001
Dedicated to the memory of Harry Lehmann, 19 pages; revised version (proof of Lemma 3.4 corrected)
Borchers, H. J., Buchholz, D., Schroer, B.   +2 more
openaire   +4 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

S-matrix bootstrap and non-invertible symmetries

Journal of High Energy Physics
We initiate the S-matrix bootstrap analysis of theories with non-invertible symmetries in (1+1) dimensions. Our previous work [1] showed that crossing symmetry of S-matrices in such theories is modified, with modification characterized by the fusion ...
Christian Copetti, Lucía Córdova, Shota Komatsu   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

MATRIX TRANSFORMATIONS OF c0(p,s), 100(p,s) and l(p,s) INTO Q

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 1997
Necessarv and sufficicnt condi­ , tions haYe been cstablished for an infini te matrix A= (͙k) to transform c0(p,s) , f.00(p,s) and ((p,s) into Q (semipcriodic scqucnces space), \vhere c0(pšs) and e00( p,s) the set of aJJ complex sequenccs X= (xk) such ...
MİKAİL ET, METİN BAŞARIR
doaj   +1 more source