Results 111 to 120 of about 4,282,430 (283)
Fatigue properties of the HSLA steel in high and ultra-high cycle region
Production Engineering Archives, 2014 This work presents a study of the fatigue properties in the example of Swedish steel Hardox 400. Fatigue tests were carried out in the area of high and ultra-high cycle region.
Robert Ulewicz +3 more
doaj
Work affected layer and fatigue properties of shot peened maraging steel
Nihon Kikai Gakkai ronbunshuThe work affected layer of shot peened maraging steel was examined and fatigue properties of the steel were investigated under rotating bending in relative humidity of 25 % and 85 %.
Norio KAWAGOISHI +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Weld Line Fatigue Analysis of Metro Carbody Based on Master S-N Curve Method
机车电传动, 2012 FEA model of a B-type metro aluminum alloy carbody including weld line was established. Based on the mesh-insensitive structural stress method and main S-N curve method in ASME standard, stress concentration, fatigue life and damage were calculated for ...
YUE Yi-xin, LIU Yong-qiang, LI Xiao-feng
doaj
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Determining equivalent S-N curves for welding materials with different welding details
Hanjie xuebaoThe varying levels of stress concentration resulting from different welding details in welding structures are the primary causes of structural fatigue failure.
Hui LIU +4 more
doaj +1 more source