Results 101 to 110 of about 4,282,430 (283)
Data-Driven Method for Predicting S-N Curve Based on Structurally Sensitive Fatigue Parameters
MetalsUnder cyclic loading, almost immediately after its onset, a surface layer forms where hardening and softening processes occur. The interaction of plastic deformation traces with each other, and with other structural elements, leads to the formation of a ...
Andrey Kurkin +3 more
doaj +1 more source
STRENGTH TEST AND RELIABILITY EVALUATION OF 20CRNIMO MATERIAL (MT)
Jixie qiangdu, 2023 Low carbon alloy steel 20CrNiMo is a kind of high strength surface hardening material which was commonly used as high-quality gears. After surface nitriding, carburizing or carbonitriding quenching treatment, it has good tooth surface hardness and tooth ...
GUO YuLiang +4 more
doaj
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
On Addition Formulae for Sigma Functions of Telescopic Curves
Symmetry, Integrability and Geometry: Methods and Applications, 2013 A telescopic curve is a certain algebraic curve defined by m−1 equations in the affine space of dimension m, which can be a hyperelliptic curve and an (n,s) curve as a special case.
Takanori Ayano, Atsushi Nakayashiki
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Fatigue Behavior of 4340 Steel at Room and Elevated Temperatures: Correlating Fatigue and Tensile Testing Data [PDF]
Iranian Journal of Materials Science and EngineeringIn this study, an existing approach for estimating fatigue life using tensile data was extended and applied to 4340 steel under different temperature. The S-N and strain-life curves were plotted at 25, 200, and 350 ˚C.
Sahar Ziraki +2 more
doaj
Application of the S-N Curve Mean Stress Correction Model in Terms of Fatigue Life Estimation for Random Torsional Loading for Selected Aluminum Alloys. [PDF]
Materials (Basel), 2020 Böhm M +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source