Results 51 to 60 of about 341,736 (266)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Performance Comparison of Metaheuristic Optimization-Based Parametric Methods in Wind Turbine Power Curve Modeling

IEEE Access
Wind-based power generation, which is a safe and clean energy resource, has a widespread implementation around the world to reduce the environmental pollution, alleviate the energy crisis and provide the economic benefits.
Mehmet Yesilbudak, Ahmet Ozcan
doaj   +1 more source

Multi-damage accelerated life test based on the Birnbaum-Saunders reliability evaluation model

Journal of Asian Architecture and Building Engineering, 2023
The present study aims to reveal the deterioration law and service life of concrete durability in the saline soil area of western China. For this purpose, the indoor accelerated tests with multiple damage factors including compound salt erosion, dry-wet ...
Chenggong Lu, Zhiqiang Wei, Hongxia Qiao, Theogene Hakuzweyezu, Guobin Qiao, Kan Li, Bingrong Zhu   +6 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Research on PFC3D meso-parameters prediction model and strength simulation of backfill based on hemical-mechanical coupling

Scientific Reports
This study develops and validates a meso-parameter prediction model for backfill materials in PFC3D, enabling efficient numerical construction under varying curing ages and mix ratios.
Yong Wang, Chen Cao, Defeng Wang, Jiang Jiao, Aixiang Wu   +4 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Determination of the controlling resistance to moisture transfer during drying

Croatian Journal of Food Science and Technology, 2012
In this study the correlation between lag factor G and Page´s mathematical model parameter n was developed. Using the newly developed correlation the presence of internal or external resistance to moisture transfer during thermal drying can be verified ...
T. Jurendić
doaj  

Parameters Estimation of Proton Exchange Membrane Fuel Cell Model Based on an Improved Walrus Optimization Algorithm

IEEE Access
Proton Exchange Membrane Fuel Cells (PEMFCs) play a crucial role in the advancement of clean hydrogen vehicles. Their ability to convert hydrogen into electricity makes them promising candidates to replace conventional engines.
Ayedh H. Alqahtani, Hany M. Hasanien, Mohammed Alharbi, Sun Chuanyu   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source