Results 71 to 80 of about 358,280 (266)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Weak Scattering of Young's Diffractive Light Wave From a Spatially Deterministic Medium

IEEE Photonics Journal, 2016
We study the modeling of the scattering of Young's diffractive light wave from a 3-D medium of which the refractive index is a deterministic function of position.
Jia Li, Feinan Chen, Liping Chang
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A New One-Parameter Gamma Family Derived via Fractional Differential Equations and Its Application to Malaria Indicator Data

Journal of Probability and Statistics
In this work, we use a fractional differential equation to create a new family of one-parameter probability distributions. We build a generalized version of the typical exponential-type model using methods from fractional calculus, namely, the UD ...
Kamaldeen Olomoda Isiak
doaj   +1 more source

TransLiteUNet: A Lightweight CNN–Transformer Hybrid for Efficient 3D Brain Tumor Segmentation with Sub-0.5 M Parameters

Journal of Imaging
Transformer, with its unique self-attention mechanism, naturally excels in modeling global features. Convolutional Neural Networks (CNNs), on the other hand, leverage strong spatial inductive biases to effectively capture local features with fewer ...
Lixin Zhou, Yuanyuan Yang, Yunfeng Yang
doaj   +1 more source

A Lumped-Parameter Equivalent Circuit Modeling for S-Shaped I–V Kinks of Organic Solar Cells

Crystals, 2019
We propose an improved lumped-parameter equivalent circuit model to describe S-shaped I⁻V kinks observed from organic solar cells. Firstly, to predict the S-shaped I⁻V kinks accurately in both the first and fourth quadrants, a shunt resistor ...
Tiankuo Wei, Chuanzhong Xu, Wei Lin, Gongyi Huang, Fei Yu   +4 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Constitutive Relationship Modeling and Characterization of Flow Behavior under Hot Working for Fe–Cr–Ni–W–Cu–Co Super-Austenitic Stainless Steel

Metals, 2015
The hot deformation behavior of a Fe–22Cr–25Ni–3.5W–3Cu–1.5Co super-austenitic stainless steel was investigated using isothermal compression tests with a wide range of temperatures (1173–1373 K) and strain rates (0.1–10 s−1).
Li-Chih Yang, Yeong-Tsuen Pan, In-Gann Chen, Dong-Yih Lin   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Resistance welding parametric modeling based on CATIA CAA

Journal of Hebei University of Science and Technology, 2019
There′re numbers of welding spots and types in vehicle seat framework (VSF) and high welding quality requirement, while commercial CAD weld design has low efficiency and cannot satisfy customers′ requirement, so it′s urgent to realize automated ...
Huawei CHEN, Quan WU, Weiping XU, Geng TANG   +3 more
doaj   +1 more source