Results 151 to 160 of about 3,184,379 (291)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Evaluation of a Point-of-Care Viscoelastic Coagulation Monitor (VCM Vet) and Thromboelastography (TEG) in Bonobos (Pan paniscus). [PDF]

J Med Primatol
Roeder MM, Bapodra-Villaverde P, Mumm LE, Lynch AM, Culbreth LR, Cabot ML, Georoff TA, Minter LJ.   +7 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Early Small Airway Mechanics and Functional Correlates in Asymptomatic Smokers: An Impulse Oscillometry-Based Study. [PDF]

Lung
Aksakal A, Kerget B, Sağ A, Coşkuner MB.   +3 more
europepmc   +1 more source

Effect of N(Epsilon)-(carboxymethyl)lysine on Laboratory Parameters and Its Association withβ^SHaplotype in Children with Sickle Cell Anemia [PDF]

, 2019
Uche Samuel Ndidi, Corynne Stéphanie Ahouéfa Adanho, Rayra Pereira Santiago, Sètondji Cocou Modeste Alexandre Yahouédéhou, Sânzio Silva Santana, Vitor Valério Mafili, Thassila Nogueira Pitanga, Cleverson Alves Fonseca, Júnia Raquel Dutra Ferreira, Elisângela Vitória Adôrno, Isa Menezes Lyra, Adekunle Adekile, Cynara Gomes Barbosa, Marilda de Souza Gonçalves   +13 more
openalex   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Deciphering optical coupled resonant systems with physics-data co-driven deep neural networks. [PDF]

Light Sci Appl
Liu SY, Zhong HT, Yu XC, Zhang BL, Zhang LY, Xu Y, Zhu NH, Chen JH, Wen HS, Huang SG, Yang DQ.   +10 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Hyperpolarized MRI Detects Increased [1-¹³C]Pyruvate Metabolism in Early Liver Regeneration. [PDF]

NMR Biomed
Kjærgaard U, Lund A, Bertelsen LB, Hansen ESS, Andersen KH, Ringgaard S, Nyengaard JR, Mortensen FV, Laustsen C.   +8 more
europepmc   +1 more source

INVESTIGATION OF GLOW DISCHARGE`S ENERGY PARAMETERS IN SMALL DIAMETER LONG TUBES

, 2019
Maksym Bolotov
openalex   +2 more sources