Results 141 to 150 of about 21,633,590 (239)

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

open access: yesAdvanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi   +7 more
wiley   +1 more source

Protein Interactions: the Multiple Solvent Crystal Structures of RNAse A and Analysis of the RalA and RalBP Complex

open access: yes, 2009
In both structure and function, Ribonuclease A (RNAse A) and RalA are two very different proteins. RNAse A is an extracellular digestive enzyme that catalyzes the breakdown of 3’-5’ phosphodiester linkages in single stranded RNA.
Dechene, Michelle Christine
core  

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

open access: yesAdvanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv   +16 more
wiley   +1 more source

SLFL Genes Participate in the Ubiquitination and Degradation Reaction of S-RNase in Self-compatible Peach. [PDF]

open access: yesFront Plant Sci, 2018
Chen Q   +8 more
europepmc   +1 more source

A Microcapsule‐Integrated smRandom‐seq Platform Enables Fixation‐Free Single Microbe RNA Sequencing

open access: yesAdvanced Science, EarlyView.
We developed a microcapsule‐integrated high‐throughput fixation‐free single‐microbe RNA‐seq workflow in which microbes are encapsulated in aqueous two‐phase microcapsules for physical confinement of nucleic acids. This platform enables co‐encapsulation with barcoded beads for sequencing and reveals that fixation‐free processing enhances transcriptomic ...
Mengdi Song   +5 more
wiley   +1 more source

Structural aspects of covalent and non-covalent dimers of pancreaticribonucleases

open access: yes, 2010
The ability to retain ribonucleolytic activity in the presence of the ribonuclease inhibitor (RI) is one of the determinant of ribonucleases (RNases) cytotoxicity.
SICA, FILOMENA, MERLINO, ANTONELLO
core  

Home - About - Disclaimer - Privacy