Results 191 to 200 of about 309,430 (247)

Structural and evolutionary insights into the eukaryotic RNase MRP ribonucleoprotein complex. [PDF]

Nat Commun
Zhou B, Wang X, Wan F, Li S, Zhang X, Zhang Y, Tan M, Cao M, Shen Y, Gao R, Zhang Y, Lan P, Wu J, Lei M.   +13 more
europepmc   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Characterisation of RT Connection and RNase H Polymorphisms in HIV-1 Subtype C in Botswana. [PDF]

Viruses
Zuze BJL, Choga WT, Moraka-Mankge NO, Choga OT, Bhebhe L, Maruapula D, Phuthego T, Mokomane M, Moyo S, Gaseitsiwe S.   +9 more
europepmc   +1 more source

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Designer Dynamic DNA Nanoaggregate in Living Cell for Mitochondrial Energy Restriction

Advanced Science, EarlyView.
This study presents the Tech‐tetrahedron, a designer dynamic DNA nanoaggregate engineered for precise mitochondrial energy restriction. Its trinity‐functionalized design integrates navigable unit, telomerase‐activated latch, and self‐assembly module.
Ruijia Deng, Jing Sheng, Ben Niu, Wenjuan Fu, Yingjie Yang, Zuowei Xie, Shuang Xie, Yunxuan He, Meilin Gong, Jue Wang, Yan Pi, Ming Chen, Kai Chang   +12 more
wiley   +1 more source

A toehold-triggered switchable three-way junction protective nanoprobe for RNase H-assisted HBV rcDNA detection. [PDF]

J Nanobiotechnology
Si J, Lv S, Gao Y, Yang Z, Liang W, Shen X, Liu G, Su S, Zhu C.   +8 more
europepmc   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

Mosaic <i>DICER1</i> RNase IIIb hotspot mutation with multiple tumors: case report and literature review. [PDF]

Front Oncol
Yang P, Jin M, Zhao W, Duan C, Yu J, Qu Y, Fu L, Yu T, Wang X, Guo R, Cui C, Mei D, Su Y.   +12 more
europepmc   +1 more source

Targeting RNase H2: A dual-mechanism strategy to elevate replication stress, DNA damage, and antitumor immunity in TNBC. [PDF]

Cell Rep Med
Nguyen TQA, Zhang J, Dai H, Murat A, Du Y, McGrail DJ, Meric-Bernstam F, Lin SY.   +7 more
europepmc   +1 more source

Dynamics of an RNase H-Responsive Tetrahedral DNA Nanostructure for Efficient Intracellular microRNA Inhibition. [PDF]

Bioconjug Chem
Martins ASG, Reis SD, Baboi R, Furlan F, Cortinhas J, Carvalho FA, Santos NC, Bath J, Benson E, Pêgo AP, Moreno PMD.   +10 more
europepmc   +1 more source