Results 191 to 200 of about 309,924 (245)

Correction: Liquid-liquid phase separation mediated immune evasion of respiratory syncytial virus against oligoadenylate synthetase-RNase L pathway. [PDF]

PLoS Pathog
Hwang WY, Rosenfeld MG, Oh S, Kwon YC.
europepmc   +1 more source

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source

Structural and evolutionary insights into the eukaryotic RNase MRP ribonucleoprotein complex. [PDF]

Nat Commun
Zhou B, Wang X, Wan F, Li S, Zhang X, Zhang Y, Tan M, Cao M, Shen Y, Gao R, Zhang Y, Lan P, Wu J, Lei M.   +13 more
europepmc   +1 more source

Interference of ATP‐Binding Cassette Transporter by Functional Nano‐Delivery System for High Efficiency Management of Insecticide‐Resistant Nilaparvata lugens

Advanced Science, EarlyView.
A ZIF‐90 nanocarrier delivers dinotefuran and suppresses NlABCG3 and NlABCH1 in resistant Nilaparvata lugens. This system combines pH/ATP‐triggered release with enhanced foliar retention, improving efficacy while sparing honeybees and promoting rice growth, offering a promising resistance‐breaking strategy.
Chengshuai He, Hejun Ren, Shuo Zhang, Jikang Cheng, Hui Zhang, Jiao Liu, Sijie Wang, Congfen Gao, Yanchao Zhang, Yunhao Gao   +9 more
wiley   +1 more source

Endothelial YAP Signaling Promotes Blood‐Spinal Cord Barrier Repair in Mice After Spinal Cord Injury

Advanced Science, EarlyView.
Endothelial YAP is required for blood‐spinal cord barrier repair after spinal cord injury. YAP‐dependent vascular repair is associated with ANGPT1/PI3K/AKT signaling in vivo and may involve endothelial‐pericyte paracrine interactions. By supporting vascular remodeling, tight junction restoration, restored pericyte coverage, and astrocyte‐vascular ...
Jiawei Wang, Yaozhi He, Yanjiao Wang, Jingjing Zhang, Qishun Liang, Mengxian Jia, Yumin Wu, Zongjie Yuan, Ziwei Fan, Yuxuan Li, Huihui Zhang, Qinjiao Fu, Ying Wang, Zhihui Huang, Honglin Teng   +14 more
wiley   +1 more source

Characterisation of RT Connection and RNase H Polymorphisms in HIV-1 Subtype C in Botswana. [PDF]

Viruses
Zuze BJL, Choga WT, Moraka-Mankge NO, Choga OT, Bhebhe L, Maruapula D, Phuthego T, Mokomane M, Moyo S, Gaseitsiwe S.   +9 more
europepmc   +1 more source

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source

A toehold-triggered switchable three-way junction protective nanoprobe for RNase H-assisted HBV rcDNA detection. [PDF]

J Nanobiotechnology
Si J, Lv S, Gao Y, Yang Z, Liang W, Shen X, Liu G, Su S, Zhu C.   +8 more
europepmc   +1 more source

Mosaic <i>DICER1</i> RNase IIIb hotspot mutation with multiple tumors: case report and literature review. [PDF]

Front Oncol
Yang P, Jin M, Zhao W, Duan C, Yu J, Qu Y, Fu L, Yu T, Wang X, Guo R, Cui C, Mei D, Su Y.   +12 more
europepmc   +1 more source

Targeting RNase H2: A dual-mechanism strategy to elevate replication stress, DNA damage, and antitumor immunity in TNBC. [PDF]

Cell Rep Med
Nguyen TQA, Zhang J, Dai H, Murat A, Du Y, McGrail DJ, Meric-Bernstam F, Lin SY.   +7 more
europepmc   +1 more source