Results 151 to 160 of about 22,716,326 (258)

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Liposomal Encapsulation of Polysaccharides (LEPS) as an Effective Vaccine Strategy to Protect Aged Hosts Against <i>S. pneumoniae</i> Infection. [PDF]

Front Aging, 2021
Bhalla M, Nayerhoda R, Tchalla EYI, Abamonte A, Park D, Simmons SR, Pfeifer BA, Bou Ghanem EN.   +7 more
europepmc   +1 more source

Antimicrobial susceptibility among Streptococcus pneumoniae and Haemophilus influenzae collected globally between 2015 and 2017 as part of the Tigecycline Evaluation and Surveillance Trial (TEST)

, 2019
Zhijie Zhang,1 Meng Chen,2 Ying Yu,3 Sisi Pan,3 Yong Liu11Clinical Laboratory Department, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of China; 2Department of Rheumatology, Affiliated Hospital of Hebei University ...
Liu Y, Zhang Z, Pan S, Chen M, Yu Y
core  

The Impact of Immunoglobulins on Cardiovascular Diseases and Lipid Profiles in Elderly and Middle‐Aged Chinese Individuals: A 15‐Year Retrospective Study

Journal of Clinical Laboratory Analysis, EarlyView.
In a 15‐year retrospective study of Chinese adults over 45, we explored the links between immunoglobulins, CVDs, and lipid profiles. Temporal increases in IgG and IgA were positively associated with FFAs, offering new insights into humoral immunity and lipid metabolism, suggesting a mechanistic link between humoral immunity and dyslipidemia ...
Ya Li, Li Jiao, Yuan Gao, Xue‐Feng Ni
wiley   +1 more source

Complement Genetic Variants and FH Desialylation in <i>S. pneumoniae</i>-Haemolytic Uraemic Syndrome. [PDF]

Front Immunol, 2021
Gómez Delgado I, Corvillo F, Nozal P, Arjona E, Madrid Á, Melgosa M, Bravo J, Szilágyi Á, Csuka D, Veszeli N, Prohászka Z, Sánchez-Corral P.   +11 more
europepmc   +1 more source

Comprehensive Performance Verification of the Mindray MN2880 System in Detecting Respiratory Virus Nucleic Acids

Journal of Clinical Laboratory Analysis, EarlyView.
This study verified the analytical performance of the fully automated Mindray MN2880 system for the simultaneous detection of SARS‐CoV‐2, influenza A/B viruses, and RSV in 2852 oropharyngeal swab specimens, following CNAS‐GL039:2019, CNAS‐GL037:2019, and ISO 15189:2022 guidelines.
Jinliang Chen, Lianying Zeng, Hao Huang, Peisong Chen   +3 more
wiley   +1 more source

Altered Signal Transduction in the Immune Response to Influenza Virus and S. pneumoniae or S. aureus Co-Infections. [PDF]

Int J Mol Sci, 2021
Wilden JJ, Jacob JC, Ehrhardt C, Ludwig S, Boergeling Y.   +4 more
europepmc   +1 more source

Trends in hospitalizations for vaccine‐preventable diseases in the United States from 2014 to 2024

Journal of Hospital Medicine, EarlyView.
Abstract Background and Objectives Vaccination rates have declined in recent years, resulting in outbreaks of vaccine‐preventable diseases (VPDs) among children. We aimed to evaluate VPD hospitalization rates from 2014 to 2024 and to report associated trends in outcomes including intensive care utilization, mortality, readmissions, and costs.
Nathan M. Money, Erin Sullivan, Hannah Rector, Corrie E. McDaniel, Jessica L. Markham, Mersine A. Bryan   +5 more
wiley   +1 more source

Clinical characteristics of Mycoplasma pneumoniae compared to Streptococcus pneumoniae in hospitalized adults with community-acquired pneumonia- a prospective study

BMC Infectious Diseases
Background Streptococcus pneumoniae is the primary cause of hospitalized community-acquired pneumonia (CAP). Mycoplasma pneumoniae, though typically causing mild respiratory disease, can lead to pneumonia requiring hospitalization in adults.
Karin Hansen, Lisa Wasserstrom, Jonas Ahl, Anna C. Nilsson, Kristian Riesbeck   +4 more
doaj   +1 more source

A Model-Based Pharmacokinetic/Pharmacodynamic Analysis of the Combination of Amoxicillin and Monophosphoryl Lipid A Against S. pneumoniae in Mice. [PDF]

Pharmaceutics, 2021
Franck S, Michelet R, Casilag F, Sirard JC, Wicha SG, Kloft C.   +5 more
europepmc   +1 more source