Results 81 to 90 of about 22,716,326 (258)

Syndecan-1 Promotes Streptococcus pneumoniae Corneal Infection by Facilitating the Assembly of Adhesive Fibronectin Fibrils

mBio, 2020
Subversion of heparan sulfate proteoglycans (HSPGs) is thought to be a common virulence mechanism shared by many microbial pathogens. The prevailing assumption is that pathogens co-opt HSPGs as cell surface attachment receptors or as inhibitors of innate
Akiko Jinno, Atsuko Hayashida, Howard F. Jenkinson, Pyong Woo Park   +3 more
doaj   +1 more source

Thermal Shifts Dominate Single‐Gene Responses to Transcription‐Targeting Antibiotics

Advanced Science, EarlyView.
Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Rahul Jagadeesan, Amir M. Arsh, Vatsala Chauhan, Suchintak Dash, Pooja Ravaria, Andre S. Ribeiro   +5 more
wiley   +1 more source

scH16S‐Seq Maps Klebsiella pneumoniae‐Associated Myeloid States and Reveals a CD38–NAD Immunometabolic Axis That Impairs Lysosomal Acidification in Sepsis

Advanced Science, EarlyView.
Single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq) integrates cell‐associated bacterial 16S‐derived signals with host transcriptomes to resolve bacterial signal‐enriched myeloid states in Klebsiella pneumoniae sepsis. Complementary pharmacological and genetic analyses define a CD38–NAD immunometabolic axis connecting mitochondrial bioenergetic ...
Yangguang Li, Yilong Yu, Fang Qin, Shenxing Li, Xuanheng Li, Peizhao Liu, Juanhan Liu, Haiqing Liu, Songqi Jing, Jianghao Zou, Sicheng Li, Jiayang Li, Tao Zheng, Yun Zhao, Jianan Ren, Xiuwen Wu   +15 more
wiley   +1 more source

Genetic and Epidemiological Characterization of Streptococcus pneumoniae disease determinants. [PDF]

, 2011
The Gram-positive pathogen Streptococcus pneumoniae is a major cause of community acquired pneumonia as well as of upper respiratory tract infections such as acute otitis media and sinusitis, and invasive diseases like meningitis, bacteremia, and ...
Melchiorre, Sara
core   +1 more source

High prevalence of multi-drug resistant Streptococcus pneumoniae among healthy children in Thailand

Journal of Infection and Public Health, 2015
Summary: Antibiotic resistance in Streptococcus pneumoniae is an emerging health problem worldwide. The incidence of antimicrobial-resistant S. pneumoniae is increasing, and nasal colonization of S.
Rapee Thummeepak, Nontapat Leerach, Duangkamol Kunthalert, Udomsak Tangchaisuriya, Aunchalee Thanwisai, Sutthirat Sitthisak   +5 more
doaj   +1 more source

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

Mycoplasma Pneumoniae infections in the Maltese Islands [PDF]

, 2000
Mycoplasma pneumoniae is a free living micro-organism which is classified in the family Mycoplasmataceae. It is primarily a human respiratory pathogen and the infection may vary from a mild pharyngitis to a pneumonia. M. pneumoniae infections are usually
Portelli, Alfred V., Barbara, Christopher   +1 more
core  

Dataset S. pneumoniae and S. aureus antibiotic resistance

, 2018
Dataset S. pneumoniae and S.
Ellen E. Stobberingh (298433), Rachid Y Yahiaoui (5903006), Casper D. J. den Heijer (298428)   +2 more
core   +1 more source

Impact of the 10-valent pneumococcal conjugate vaccine on the incidence of respiratory and ENT diseases and antibiotic consumption in children under 5 years of age in Barnaul [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2018
Objective. To evaluate epidemiological efficacy of the 10-valent pneumococcal conjugated vaccine (PCV10) as assessed by the number of episodes of respiratory tract and ENT diseases and by the number of antibiotic courses prescribed for those diseases in
Kozyanova Yu.A., Safyanova T.V.
doaj  

The diagnostic value of metagenomic next-generation sequencing for identifying Streptococcus pneumoniae in paediatric bacterial meningitis

BMC Infectious Diseases, 2019
Background There is currently no research on the diagnostic value of metagenomic next-generation sequencing (mNGS) for a single pathogens in CSF.
Xi-xi Zhang, Ling-yun Guo, Lin-lin Liu, Ao Shen, Wen-ya Feng, Wen-hua Huang, Hui-li Hu, Bing Hu, Xin Guo, Tian-ming Chen, He-ying Chen, Yong-qiang Jiang, Gang Liu   +12 more
doaj   +1 more source