Results 61 to 70 of about 22,716,326 (258)
, 2008 Streptococcus pneumoniae colonizes the mucin-rich environment of the nasopharynx. As colonization may be the first stage of infection, investigation was carried out as to whether the pneumococcus could utilize mucin as a source of nutrient and whether ...
Manco, Sonia +4 more
core +1 more source
Advanced Science, EarlyView.Liquid atmospheric pressure matrix‐assisted laser desorption/ionization (LAP‐MALDI) mass spectrometry (MS) provides multiplexed biotyping of microbial cultures using a fast and simple workflow. This is demonstrated for clinically relevant bacteria, resulting in accurate antimicrobial resistance (AMR) detection, speciation by MS/MS sequencing and ...
Lily R. Adair +3 more
wiley +1 more source
Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae
Advanced Science, EarlyView.Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch +6 more
wiley +1 more source
pH‐Driven Two‐Stage Conformational Switching Activates an Acid‐Responsive Chaperone
Angewandte Chemie, EarlyView.AchC is an ATP‐independent, pH‐responsive chaperone. AchC functions as a molecular switch, sensing pH changes and undergoing a two‐stage conformational transition: C‐terminal extension (colored in yellow) loosening at mild pH 4.0–5.5 and monomerization at strong acidic pH 3.0.
Soojeong Ham +4 more
wiley +2 more sources
Risk Management and Healthcare Policy, 2020 Dejene Bayu,1 Abiyu Mekonnen,2 Jemal Mohammed,3 Dagne Bodena1 1Hiwot Fana Specialized University Hospital, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 2Department of Medical Laboratory Sciences, Menelik-II College of ...
Bayu D, Mekonnen A, Mohammed J, Bodena D
doaj
Contribution of Pili of S. Pneumoniae in the Onset of Meningitis
Folia Veterinaria, 2018 Bacterial meningitis is a devastating worldwide disease. Half of the survivors of meningitis remain with permanent neurological sequelae. The pathogenesis of meningitis is based on a complex host-pathogen interaction.
Jiménez-Munguía I. +7 more
doaj +1 more source
A Microcapsule‐Integrated smRandom‐seq Platform Enables Fixation‐Free Single Microbe RNA Sequencing
Advanced Science, EarlyView.We developed a microcapsule‐integrated high‐throughput fixation‐free single‐microbe RNA‐seq workflow in which microbes are encapsulated in aqueous two‐phase microcapsules for physical confinement of nucleic acids. This platform enables co‐encapsulation with barcoded beads for sequencing and reveals that fixation‐free processing enhances transcriptomic ...
Mengdi Song +5 more
wiley +1 more source
Advanced Science, EarlyView.Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie +10 more
wiley +1 more source
Human Vaccines & Immunotherapeutics, 2019 Streptococcus pneumoniae is an infectious pathogen mainly infecting host bodies through the respiratory system. An effective pneumococcal vaccine would be targeted to the mucosa and provide not only protection against invasive infection but also against ...
Jingcai Lu +7 more
doaj +1 more source
Бюллетень сибирской медицины, 2014 Comuunity-acquired pneumonias in aged patients is the significant epidemiology problem for the public health of almost all the countries. Even more important the problem of microbiological monitoring and epidemiology surveillance for the S.
A. V. Martynova +2 more
doaj +1 more source