Results 151 to 160 of about 15,017 (189)

Single-cell and spatial analyses reveal the effect of VSIG4+S100A10+TAMs on the immunosuppression of glioblastoma and anti-PD-1 immunotherapy.

International Journal of Biological Macromolecules
Therapeutic strategies aiming at the tumor immune microenvironment (TIME) hold promise for glioblastoma (GBM) treatment. However, adjuvant immunotherapies targeting checkpoint inhibitors just prove effective for a selected group of GBM patients.
Ziyuan Liu, Yufan Yang, Haiting Fang, Bohong Cen, Yiqi Fan, Jianlong Li, Lijie Wang, Shuai He   +7 more
semanticscholar   +1 more source

Integrating single cell analysis and machine learning methods reveals stem cell-related gene S100A10 as an important target for prediction of liver cancer diagnosis and immunotherapy

Frontiers in Immunology
Background Hepatocellular carcinoma (LIHC) poses a significant health challenge worldwide, primarily due to late-stage diagnosis and the limited effectiveness of current therapies.
Shenjun Huang, Tingting Tu
semanticscholar   +1 more source

Differential expression of S100A10 protein in leukocytes and its effects on monocyte emigration from bone marrow.

Journal of Immunology
Although the importance of the unique member of S100 EF-hand family, S100A10 in health and disease is well appreciated, a precise characterization of S100A10 expression still remains elusive.
Yuxin Zhao, Shan Jiang, Yang Lv, Jingtao Gao, Lichen Zhang, Xueqin Tian, Xiaohang Sheng, Han Wang, Cun Guo, Wei Lu, Chuang Li, Tingmin Chang, Yunwei Lou, Hui Wang   +13 more
semanticscholar   +1 more source

Cell-Free Expression of HPV16 Minor Capsid Protein L2 and Its Interaction with S100A10.

Protein Peptide Letters
BACKGROUND Human papillomavirus type 16 (HPV16) is implicated in various malignancies. The virus enters host cells through endocytosis, during which the minor capsid protein L2 interacts with the S100A10 subunit of the annexin A2 heterotetramer (A2t) on ...
Wenqi Jiang, Lian Wu, Xiangchun Shen, Q. Fu   +3 more
semanticscholar   +1 more source

S100A10 regulates plasminogen-dependent macrophage invasion

Blood, 2010
Abstract The plasminogen activation system plays an integral role in the migration of macrophages in response to an inflammatory stimulus, and the binding of plasminogen to its cell-surface receptor initiates this process. Although previous studies from our laboratory have shown the importance of the plasminogen receptor S100A10 in ...
Paul A, O'Connell, Alexi P, Surette, Robert S, Liwski, Per, Svenningsson, David M, Waisman   +4 more
openaire   +2 more sources

Multi-omics analysis identifies S100a10/Anxa2 complex within proximal tubule aggravates acute kidney injury through p-Stat3/Spp1 signaling.

Translational research : the journal of laboratory and clinical medicine
BACKGROUND Acute kidney injury (AKI) has become a global public health problem that seriously endangers human health, the treatment for AKI is mainly supportive and there is no targeted, efficient and low-toxicity treatment.
Zhejun Chen, Liqing Ye, Minyan Zhu, Xi Lin, Jiajia Wu, Xiang Zhang, Yifei Wang, Xia Hong, Zhiyu Li, Shouci Hu, Wen Zhang, Peipei Zhang, Hongbo Chen   +12 more
semanticscholar   +1 more source

Disruptions of p11 (S100A10) and HPA Axis Homeostasis Participate in the Major Depressive Disorder (MDD) Especially in Female Patients

Neuropsychiatric Disease and Treatment
Objective Patients suffering from major depressive disorder (MDD) commonly exhibit abnormal p11 (S100A10) and dysregulation of the hypothalamic–pituitary–adrenocortical (HPA) axis.
Yingying Yue, Jialin Zhang, Yinghui Li, Xuxia Ma, Gang Chen, Zixin Zhu, Suzhen Chen, Ying Chen, Linlin You, L. Tan, Wenhao Jiang, Yonggui Yuan   +11 more
semanticscholar   +1 more source

Abstract 3985: S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos

Cancer Research, 2023
Growing evidence indicates that tumor cells exhibit characteristics similar to their lineage progenitor cells. We found that S100 calcium binding protein A10 (S100A10) exhibited an expression pattern similar to that of liver progenitor genes.
Lu Tian, Xia Wang, Jingyi Lu, Hongyang Huang, Goofy Yu-Man Tsui, K. Sze, T. Cheung, I. Ng   +7 more
semanticscholar   +1 more source

Abstract 3966: Targeting S100A10, a SOX9 binding protein, for the treatment of triple negative breast cancer

Cancer Research, 2023
Background: Triple-negative breast cancers (TNBCs) are the most aggressive breast cancers and have a very poor prognosis. Since TNBCs lack the expression of the estrogen receptor (ER), human epidermal growth factor receptor 2 (HER2), and progesterone ...
Yanxia Ma, J. Qian, Cassandra L Moyer, A. Lanier, Jamal L Hill, Darian Coleman, D. Hawke, A. Mazumdar, P. Brown   +8 more
semanticscholar   +1 more source

Shh-S100A10 axis curbs neuronal PANoptosis after ischemic stroke.

Neural Regeneration Research
Acute ischemic stroke is a highly prevalent and disabling disease with poor prognosis. Neuronal death is a major feature after a stroke. PANoptosis is a newly reported pattern of cell death, characterized by pyroptosis, apoptosis, and necroptosis, that ...
Ling Wang, Hao Tang, Jun Wen, Qin Yang, Jiagui Huang, Yong Zhao, Yu Ren, Qin Yang   +7 more
semanticscholar   +1 more source