Results 131 to 140 of about 25,225,437 (145)

Tirzepatide Persistence and Associated Changes in Clinical Outcomes in US Adults With Obesity or Overweight: A 6‐Month Claims Database Analysis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Tirzepatide is a once‐weekly glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) approved in the US for the treatment of Type 2 diabetes (T2D), weight loss and obstructive sleep apnoea. This study aimed to assess the utilisation and effectiveness of tirzepatide among individuals in a large ...
Theresa Hunter Gibble, Malvika Venkataraman, Donna Mojdami, Carlos Vallarino, Grace Stockbower, Michael Grabner, Mythili Ananth, Karishma Desai   +7 more
wiley   +1 more source

Multi‐Dimensional Barriers for Work Productivity and Possible Solutions to Overcome Presenteeism in Young‐Onset Diabetes: A Mixed‐Methods Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Young‐onset non‐type 1 diabetes (YOD, age‐at‐diagnosis ≤ 40) is associated with poor physical and mental health, presenteeism and productivity loss. We examined patient‐perceived barriers to work productivity and key enablers to reduce presenteeism. Materials and Methods In this mixed‐methods study, we utilized validated questionnaires to
Kelly T. C. Wong, Jason D. C. Yin, Sunny C. S. Chan, Nga Sze Wong, Chun‐Kwan O, Yiming Dai, Yuzheng Zhang, Marques S.N. Ng, Risa Ozaki, Ronald C. W. Ma, Alice P. S. Kong, Andrea O. Y. Luk, Elaine Y.K. Chow, Juliana C. N. Chan, Juliana N. M. Lui   +14 more
wiley   +1 more source

Oral Butyrate Reduces Progression of Kidney Damage in an L‐NAME‐Induced Diabetic Kidney Disease Mouse Model

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Diabetic kidney disease (DKD) is one of the main causes of kidney failure worldwide. Interestingly, patients affected by DKD are characterised by a low abundance of gut bacteria producing short fatty acids including butyrate, which is suggested to play a role in the decline of renal function.
Maria Novella Nicese, Angela Koudijs, Reshma Lalai, Cristina Avramut, Rico J. E. Derks, Elena Sánchez‐López, Martin Giera, Amanda C. M. Pronk, Artemiy Kovynev, Sander Kooijman, Patrick C. N. Rensen, Roel Bijkerk, Bernard M. van den Berg, Joris I. Rotmans   +13 more
wiley   +1 more source

The depth and breadth of capitalism at the Cape

The Economic History Review, EarlyView.
Abstract Limited liability company legislation was introduced to the Cape Colony in 1861. An amendment in 1892 led to wider adoption, expanding and diversifying the capital market. Using novel data from the Cape Joint Stock Archive between 1892 and 1902, this paper examines who invested, where capital flowed, and how these patterns shaped firm outcomes
Edward Kerby, Lloyd Melusi Maphosa
wiley   +1 more source

Innovation and the great divergence

The Economic History Review, EarlyView.
Abstract Recent historical national accounting data show that the timing of the Great Divergence hinges on the different trends in north‐west Europe and the Yangzi Delta region of China. Although north‐west Europe only pulled ahead of the Yangzi Delta after 1700, both the positive trend of GDP per capita in north‐west Europe after 1700 and the negative
Stephen Broadberry, Runzhuo Zhai
wiley   +1 more source

Real‐World Diagnostic Patterns and Symptom Progression in Aspirin‐Exacerbated Respiratory Disease

Clinical &Experimental Allergy, EarlyView.
Orli Weiser, Guy Melamed, Ronit Confino‐Cohen, Yossi Rosman   +3 more
wiley   +1 more source

Relationship Between Self‐Reported Bruxism and Perceived Stress Among Brazilian Health Science Students

European Journal of Dental Education, EarlyView.
ABSTRACT Objectives Investigate the relationship between perceived stress and self‐reported bruxism among health science students, as well as to map the instruments used to assess both variables. Methods A total of 545 students from health science programs at the UNIFAL‐MG participated in this cross‐sectional study, which used the Self‐Reported Bruxism
Lizandra Oliveira Cunha, Mariana Martins de Vitro, Ihanael Ifanger, François Isnaldo Dias Caldeira, Allan Saj Porcacchia, Heloisa de Sousa Gomes, Nilton Jóse da Silva‐Filho, Ticiana Sidorenko de Oliveira Capote, Larissa Santana Rodriguez, Diego Girotto Bussaneli   +9 more
wiley   +1 more source

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source

ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis

The FEBS Journal, EarlyView.
The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati, Chandra Sekhar Yadavalli, Md Monirul Hoque, Swapna Thota, Gadiparthi N. Rao   +4 more
wiley   +1 more source

Migration‐related inequalities in HIV diagnosis, treatment initiation and retention in care among migrants in Greece

HIV Medicine, EarlyView.
Abstract Objectives Migrants account for a substantial proportion of people living with HIV in Europe, yet inequalities across the HIV care continuum remain insufficiently characterized. We examined migration‐related differences in HIV diagnosis, treatment initiation and retention in care in Greece.
Nikos Pantazis, Varvara Vasalou, Olga Tsachouridou, Vasileios Papastamopoulos, Konstantinos Protopapas, Myrto Astriti, Maria Chini, Mina Psichogiou, Georgios Chrysos, Nikolaos V. Sipsas, Helen Sambatakou, Markos Marangos, Diamantis Kofteridis, Periklis Panagopoulos, Giota Touloumi, on behalf of AMACS, G. Adamis, M. Chini, G. Chrysos, M. Marangos, O. Katsarou, D. Kofteridis, S. Metallidis, P. Panagopoulos, N. Pantazis, A. Papadopoulos, V. Paparizos, V. Papastamopoulos, M. Psichogiou, H. Sambatakou, NV. Sipsas, G. Touloumi   +31 more
wiley   +1 more source