Results 321 to 330 of about 620,969 (398)

Structural analyses of ABA transporters give new impetus to the study of ABA regulation

open access: yesAnnals of Applied Biology, EarlyView.
Abscisic acid (ABA) regulates key physiological processes and coordinates abiotic stress responses. In the six decades since it was first described, a huge amount of work has been conducted on ABA synthesis, breakdown and signalling mechanisms. Recently, attention has been turned to the role of ABA transporters, and the elucidation in exquisite detail ...
Navneet Kaur   +2 more
wiley   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

open access: yesBritish Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

A CRISPR‐Cas9‐based system for the dose‐dependent study of DNA double‐strand break sensing and repair

open access: yesThe FEBS Journal, EarlyView.
Using CRISPR‐Cas9, we engineered a genetic system allowing the dose‐dependent induction of a controllable number of DNA double‐strand breaks in Saccharomyces cerevisiae. The tool was used to study the kinetics of DNA break sensing and repair, including the spatial distribution of Tel1ATM kinase, which initiates the DNA damage response.
Morgane Auboiron   +5 more
wiley   +1 more source

Short coiled‐coil proteins from plants and metazoans – the ‘jacks of all trades’

open access: yesThe FEBS Journal, EarlyView.
Short coiled‐coil proteins from plants and metazoans—true ‘jacks of all trades’—play supporting but crucial roles in cellular stress response, metabolism, autophagy, and membrane dynamics. Despite their small size and modest sequence conservation, proteins like plant LSUs and metazoan SCOCs showcase remarkable functional versatility shaped by evolution,
Agnieszka Sirko   +2 more
wiley   +1 more source

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