Results 11 to 20 of about 6,494 (215)

Gradient-Adaptive Pareto Optimization for Constrained Reinforcement Learning [PDF]

open access: yes, 2023
Constrained Reinforcement Learning (CRL) burgeons broad interest in recent years, which pursues maximizing long-term returns while constraining costs.
Huang, Mengda   +6 more
core   +1 more source

MFAFNet: A Lightweight and Efficient Network with Multi-Level Feature Adaptive Fusion for Real-Time Semantic Segmentation [PDF]

open access: yes, 2023
Currently, real-time semantic segmentation networks are intensely demanded in resource-constrained practical applications, such as mobile devices, drones and autonomous driving systems.
Hua Li   +3 more
core   +1 more source

Death happy: Adaptive ageing and its evolution by kin selection in organisms with colonial ecology [PDF]

open access: yes, 2021
Standard evolutionary theory, supported by mathematical modelling of outbred, dispersed populations predicts that ageing is not an adaptation. We recently argued that in clonal, viscous populations, programmed organismal death could promote fitness ...
Gems, D, Galimov, ER
core  

Long-Term Adaptive Modeling for Autonomous Underwater Vehicles [PDF]

open access: yes, 2020
Autonomous Underwater Vehicles (AUV)s are robotic systems designed as an alternative to manned submerged vehicles, to carry out specific and well-defined underwater tasks. As part of their development process, modeling the hydrodynamicbehaviour of these
Wehbe, Bilal
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Estimation of parameters for macroparasite population evolution using approximate Bayesian computation [PDF]

open access: yes, 2011
We estimate the parameters of a stochastic process model for a macroparasite population within a host using\ud approximate Bayesian computation (ABC). The immunity of the host is an unobserved model variable and only mature\ud macroparasites at sacrifice
Pettitt, Anthony N.   +1 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Effect of long-term treatment with pramipexole or levodopa on presynaptic markers assessed by longitudinal [123I]FP-CIT SPECT and histochemistry. [PDF]

open access: yes, 2013
A previous clinical trial studied the effect of long-term treatment with levodopa (LD) or the dopamine agonist pramipexole (PPX) on disease progression in Parkinson disease using SPECT with the dopamine transporter (DAT)-radioligand [(123)I]?-CIT as ...
Depboylu, C;Maurer, L;Matusch, A;Hermanns, G;Windolph, A;Behe, M;Oertel, WH;Hoglinger, GU
core   +3 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

open access: yesFEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy