Results 51 to 60 of about 16,694 (284)

Multiscale Hierarchical Patterning by Sacrificial Layer‐Assisted Creep Lithography [PDF]

, 2019
The capability to fabricate various multiscale structures without limitations of size, morphology, and number of hierarchies via a simple process is highly desired in modern research.
Shin, Minho, Yeon, Je Hyeon, Segeun Jang, Je Hyeon Yeon, Kim, Sang Moon, Sang Moon Kim, Minho Shin, Choi, Mansoo, Jang, Segeun, Mansoo Choi, Choi, Jiwoo, Jiwoo Choi   +11 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Water-soluble sacrificial 3D printed molds for fast prototyping in ceramic injection molding [PDF]

, 2021
Fabrication of steel molds is a major expense (time and cost) in ceramic injection molding research and development. 3D printed resin molds for fast prototyping are therefore highly attractive and have gained increasing attention.
Tschamper, Maurice, Wick-Joliat, René, Kontic, Roman, Penner, Dirk   +3 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Subtractive manufacturing with swelling induced stochastic folding of sacrificial materials for fabricating complex perfusable tissues in multi-well plates

Lab on a Chip, 2022
We developed a subtractive manufacturing with swelling induced stochastic folding of sacrificial materials for fabricating complex perfusable tissues in high-throughput multi-well plate formats.
Shravanthi Rajasekar, Dawn S. Y. Lin, Feng Zhang, Alexander Sotra, Alex Boshart, Sergi Clotet-Freixas, Amy Liu, Jeremy A. Hirota, Shinichiro Ogawa, Ana Konvalinka, Boyang Zhang   +10 more
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Ceci n’est pas un autel, ceci est un autel ! À propos de quelques jeux d’images rituelles à Rome

Images Re-Vues, 2020
The article focuses on ancient Roman reliefs and their potential for reflexivity. It looks at the echoes of images and sacrificial rituals by analyzing mainly three monuments.
Valérie Huet
doaj   +1 more source

SACRIFICIAL COMPLEXES OF UST-VAGILSKY HILL ON THE TAVDA RIVER (BASED ON THE MATERIALS OF EXCAVATIONS IN 1970)

Вестник Пермского университета. История, 2023
Ust-Vagilsky Hill is an unusual cult site in the form of a hill with a diameter of about 50 m and a height of up to 6 m is located in the upper reaches of the Tavda river (Garinsky district of the Sverdlovsk region). All epochs from the Mesolithic to the Middle Ages are represented on the hill. Each epoch is characterized by its own features.
openaire   +2 more sources