Results 61 to 70 of about 54,356 (248)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Sample-Adaptive Coding Scheme (SACS): A Structurally Constrained Vector Quantizer [PDF]
, 1998 In this paper, we propose a novel feed-forward adaptive coding scheme called SACS (sample adaptive coding scheme) for the lossy compression of a discrete-time memoryless stationary source.
Kim, Dong Sik, Shroff, Ness B.
core +1 more source
Screening Diabetic Retinopathy in Developing Countries using Retinal Images
Applied Medical Informatics, 2015 In developing countries, diabetic retinopathy (DR) is the leading cause of blindness in diabetic patients due to intraocular hypertension or high glucose level.
D. SIVA SUNDHARA RAJA, S. VASUKI
doaj
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Acta Cirúrgica Brasileira, 2006 PURPOSE: Investigated the effect of intraluminal short-chain fatty acids (SCFA) on the intestinal mucosa in the presence of ischemia-reperfusion injury (IRI). METHODS: Six blind sacs of the small bowel (3at the jejunum and 3 at the ileum) were created in
Aguilar-Nascimento José Eduardo de +4 more
doaj
Recent advances in high-loading single-atom catalysts
Next MaterialsSingle-atom catalysts (SACs) have unique advantages over traditional nanoparticle-based catalysts. They are promising for various green energy technology applications. However, single atoms with high surface energy are prone to aggregation.
Chengli Rong +3 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Macroanatomic studies on the stomach of camel [PDF]
Eurasian Journal of Veterinary SciencesWork was undertaken to elucidate the macroanatomic details of the stomach of the camel. Fifteen adult healthy one-humped camels (Camelus dromedarius) were used. The abdominal organs were kept in situ and their relations to the stomach were examined.
Hasan Erden +4 more
doaj
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source