Results 51 to 60 of about 54,356 (248)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

SOME TOPOGRAPHICAL AND MORPHOLOGICAL STUDIES ON AIR SACS OF DOMESTIC PIGEON (COLUMBA LIVIA DOMESTICA) USING CORROSION CASTS [PDF]

open access: yesVeterinary Medical Journal - Giza, 2005
The work was carried out on fifteen adult pigeons of both sexes. The gross morphological features of the air sacs were thoroughly investigated using Vinyl chloride acetate corrosion casts.
El-Mahdy M
doaj   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Affine with B-Spline Registration based Retrieval using Distance Metrics

open access: yesApplied Medical Informatics, 2014
Developing a two stage framework is the purpose dealt in this paper. This rely on the Affine transformation and B –Spline for registration of medical images as the first stage of the framework and retrieval of medical images using distance metrics as the
Swarnambiga AYYACHAMY
doaj  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

SaCS: A Method and a Pattern Language for the Development of Conceptual Safety Design [PDF]

open access: yes, 2014
Flight control systems, railway interlocking systems, and nuclear reactor protection systems are examples of safety critical systems from different industrial domains.
Hauge, André Alexandersen
core  

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Main-group metal elements as promising active centers for single-atom catalyst toward nitric oxide reduction reaction

open access: yesnpj 2D Materials and Applications, 2022
Current research efforts on single-atom catalysts (SACs) exclusively focus on nonmetal or transition-metal atoms as active centers, while employing main-group metal elements is seemingly excluded because their delocalized s/p-bands are prone to yield a ...
Qian Wu   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Single-atom catalysts supported on atomically thin materials for water splitting

open access: yesAdvanced Powder Materials
Single-atom catalysts (SACs) have demonstrated exceptional performance in electrocatalytic water splitting, owing to their maximized atomic utilization efficiency and superior reaction kinetics. The incorporation of SACs typically depends on robust metal-
Xiaomin Chen   +8 more
doaj   +1 more source

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