Results 131 to 140 of about 262,483 (141)

Identification of TMEM41B TM6 as a critical domain for coronavirus replication <i>in vitro</i> and <i>in vivo</i>. [PDF]

J Virol
Fang P, Xiao W, Wang X, Xiong Y, Ding T, Cheng T, Chen C, Xiao S, Fang L.   +8 more
europepmc   +1 more source

Concanavalin A targets phylogenetically conserved N-linked glycans on coronavirus spike proteins for broad-spectrum antiviral activity. [PDF]

J Virol
Guo D, Yu S, Ma K, Tao H, Wang Q, Han S, Ai Q, Hu H, Ma X, Li G, Wang S.   +10 more
europepmc   +1 more source

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SADS‐CoV nsp1 inhibits the IFN‐β production by preventing TBK1 phosphorylation and inducing CBP degradation

Journal of Medical Virology, 2023
AbstractSwine acute diarrhea syndrome (SADS) is first reported in January 2017 in Southern China. It subsequently causes widespread outbreaks in multiple pig farms, leading to economic losses. Therefore, it is an urgent to understand the molecular mechanisms underlying the pathogenesis and immune evasion of Swine acute diarrhea syndrome coronavirus ...
Yingjie, Xiang, Chunxiao, Mou, Kaichuang, Shi, Xiang, Chen, Xia, Meng, Wenbin, Bao, Zhenhai, Chen   +6 more
openaire   +2 more sources

SADS-CoV Nsp1 hijacks proteasomal subunits to degrade IRF1

Veterinary Microbiology
Swine Acute Diarrhea Syndrome Coronavirus (SADS-CoV) is an emerging porcine enteric coronavirus that causes severe diarrhea in piglets. Type III interferon (IFN) are crucial for intestinal antiviral defense, and the capacity of SADS-CoV to disrupt IFN-III responses is critical for its replication.
Yingjie, Xiang, Qinyuan, Zhu, Yue, Cheng, Xing, Zhao, Kaichuang, Shi, Shuping, Feng, Yu, Huang, Zhenhai, Chen, Changhua, Lin, Chunxiao, Mou   +9 more
openaire   +2 more sources

Prohibitin of swine antagonizes SADS-CoV replication and virus-induced apoptosis

Journal of General Virology
Swine acute diarrhoea syndrome coronavirus (SADS-CoV) is an enveloped, single-stranded positive-sense RNA virus that causes acute diarrhoea and death in piglets, resulting in significant economic losses to the pig farming industry. Studying the interaction patterns between SADS-CoV and host proteins can provide guidance for the development of antiviral
Jingya Xu, Cheng Li, Tuoxin Huang, Ling Zhou, Xiaoya Zhao, Yuan Sun, Jingyun Ma   +6 more
openaire   +2 more sources

Identification of CASC3 as a Novel SADS-CoV Restriction Factor Through Liquid-Liquid Phase Separation Inhibiting Viral Replication

Veterinary Microbiology
Swine acute diarrhoea syndrome coronavirus (SADS-CoV) is a newly emerging highly pathogenic virus that likely originated from the closely related HKU2 bat coronaviruses. The cross-species transmission potential of the virus not only caused colossal economic losses but also threatened public health.
Kankan Yang, Lunguang Yao
exaly   +5 more sources

SADS-CoV N protein antagonizes JAK-STAT signaling pathway by targeting STAT1 for degradation

Veterinary Microbiology
In recent years, Swine Acute Diarrhea Syndrome Coronavirus (SADS-CoV) has attracted our attention as a new outbreak of porcine coronavirus. Reports on SADS-CoV indicate that this virus is widely involved in innate immunity, but its mechanism of involvement in antagonizing interferon signaling is still unclear.
Meiqi, Liu, Jiarui, Li, Yingjie, Xiang, Kaichuang, Shi, Lindong, Li, Zhong, Du, Xiaorou, Zheng, Zhenhai, Chen, Chunxiao, Mou   +8 more
openaire   +2 more sources

Re-emergence of severe acute diarrhea syndrome coronavirus (SADS-CoV) in Henan, central China, 2023

Veterinary Microbiology
Severe acute diarrhea syndrome coronavirus (SADS-CoV) was first detected in Guangdong province of China in 2017. And yet from May 2021 to Jun 2023, there were no SADS-CoV outbreaks. In this study, we reported the recent outbreak of SADS-CoV in China on Jun 2023. Phylogenetic analysis showed the novel strain was derived from the ongoing transmission and
Teng, Zhang, Jiale, Yao, Zhuan, Yang, Jucai, Wang, Kankan, Yang, Lunguang, Yao   +5 more
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AS-IV Exhibits Anti-SADS-CoV Effects Through the Inhibition of the MAPK/JNK Signaling Pathway Mediated by the S1 Protein

Veterinary Microbiology
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a porcine intestinal alpha coronavirus that infects newborn piglets. Clinical symptoms include acute diarrhea, vomiting, dehydration, and death. There is no effective prevention and control vaccine yet, so new measures are urgently needed, including antiviral strategies.
Guihong Zhang, Shuiping Liu, Dengju Guo
exaly   +3 more sources

Transcriptomic-proteomic integration reveals RNGTT as a critical host factor mediating the replication of virulent but not attenuated SADS-CoV

Veterinary Microbiology
Swine acute diarrhea syndrome coronavirus (SADS-CoV) causes severe economic losses to the swine industry. This study aimed to identify host targets differentially expressed between virulent and attenuated SADS-CoV infections via multi-omics analysis for antiviral drug development. IPI-FX cells were infected with SADS-CoV virulent P17 or attenuated P117
Zexin Chen, Yihui Huang, Mingchong Li, Ouyang Peng, Jun Luo, Yue Pan, Zhanpeng Kuang, Zhichao Xu, Yongchang Cao, Xiaona Wei, Chunyi Xue   +10 more
openaire   +2 more sources