Results 41 to 50 of about 339,904 (294)
Financial InnovationThis article investigates five safe-haven asset responses from 2014 to 2022, including the unprecedented COVID-19 crisis, Russian invasion of Ukraine, and sharp US interest rate increases of 2015 and 2022. We apply the unique approach of the multivariate
Ewa Feder-Sempach +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Summertime overheating in UK homes: is there a safe haven?
Buildings & Cities, 2021 Summertime overheating in dwellings in temperate climates is widespread. Overheating in bedrooms disrupts sleep, degrading health and wellbeing, and can be life-threatening.
Paul Drury +2 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Replacing Safe Havens with a Safe System [PDF]
Journal of Money Laundering Control, 1999 In recent weeks, there has been a major crash in the middle of the financial services electronic highway, and hundreds of millions of people are already feeling the shock from the impact, even if they were nowhere near the site of the impact in Moscow.
openaire +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives WHO grade 4 astrocytomas are associated with poor prognosis, and their prognostic factors remain controversial. This study aimed to identify the prognostic factors and develop a management algorithm for these patients. Methods This study retrospectively included 151 CNS5 adult grade 4 astrocytomas from two medical centers.
Jiawei Cai +13 more
wiley +1 more source
Discrete Dynamics in Nature and SocietyThis article assesses the hedging and safe haven properties of energy and agricultural commodities (crude oil, natural gas, and wheat) against the G7 stock market indices and banking sector stock indices during the COVID-19 pandemic, the Russia–Ukraine ...
Yasmine Snene Manzli +2 more
doaj +1 more source
International Journal of Population Data Science, 2023 There has been a recent emphasis to establish and codify large-scale or national Trusted Research Environments (TREs) in the United Kingdom, with a view to limit smaller, local TREs.
Katherine O'Sullivan, Katie Wilde
doaj +1 more source
Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi +19 more
wiley +1 more source