Results 101 to 110 of about 3,072,572 (310)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Development of predicting model for safety behaviour based on safety psychology and working environment [PDF]

, 2018
The increasing trend of occupational accident due to unsafe act and unsafe condition especially in construction site suggests the need for more proactive safety assessment model.
Md Asari, Mohammad Khairul Shaleh
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Exposure and risk assessment for agricultural workers during chlorothalonil and flubendiamide treatments in pepper fields

Scientific Reports
Pesticides are indispensable tools in modern agriculture for enhancing crop productivity. However, the inherent toxicity of pesticides raises significant concerns regarding human exposure, particularly among agricultural workers.
Deuk-Yeong Lee, Jong-Wook Song, Ji-Young An, Yeong-Jin Kim, Jong-Su Seo, Jong-Hwan Kim   +5 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Study on the species-level distribution and antimicrobial resistance of Cronobacter spp. isolated from condiments and cereal-based foods across 19 provinces (autonomous regions, municipalities) in China

Zhongguo shipin weisheng zazhi
ObjectiveTo explore the species-level distribution and antimicrobial resistance of Cronobacter spp. isolated from condiments and cereal-based foods across 19 provinces （autonomous regions， municipalities） in China， and provide data support for analyzing ...
LI Menghan, ZHENG Jieying, ZHAO Jianyun, WU Weiliang, BAI Li, GAN Xin   +5 more
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Alternaria toxins in various food marketed in China and dietary exposure assessment

Zhongguo shipin weisheng zazhi
ObjectiveTo investigate occurrence of alternaria toxins various food marketed in China， and to evaluate dietary exposure and their potential health risks.MethodsA total of 7 694 samples of 11 types foods， including wheat flour， bread， and tomato sauce ...
YANG Xin, YAN Zhaofeng, PAN Feng, GUO Yuan, HUANG Changgang, SHAO Yi, YANG Dajin   +6 more
doaj   +1 more source

Safety assessment for EPS electron-proton spectrometer [PDF]

A safety analysis was conducted to identify the efforts required to assure relatively hazard free operation of the EPS and to meet the safety requirements of the program.
Gleeson, P.
core   +1 more source