Results 81 to 90 of about 3,040,361 (309)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Quantitative risk model of hazardous chemicals in foodstuffs in computer system

Zhongguo shipin weisheng zazhi, 2020
Objective To quickly and automatically evaluate the risk of hazardous chemical substances in food quickly and automatically. Methods Based on the Spring MVC framework, a quantitative assessment model of food chemicals was integrated and a visualization ...
Liang SU, Lei ZHANG, Pengcheng REN, Zhixing LI, Yanan WANG, Ceng CEN, Chen XU, Zhaoping LIU, Pingping ZHOU   +8 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The New Food Safety [PDF]

, 2019
A safe food supply is essential for a healthy society. Our food system is replete with different types of risk, yet food safety is often narrowly understood as encompassing only foodborne illness and other risks related directly to food ingestion.
Broad Leib, Emily M., Pollans, Margot J.
core   +1 more source

Dynamic safety assessment of a nonlinear pumped-storage generating system in a transient process [PDF]

, 2019
This paper focuses on a pumped-storage generating system with a reversible Francis turbine and presents an innovative framework for safety assessment in an attempt to overcome their limitations.
Abbassi, Rouzbeh, Arzaghi, Ehsan, Caraballo Garrido, Tomás, Chen, Diyi, Gao, Xiang, Kilicman, Adem, Li, Huanhuan, Patelli, Edoardo, Xu, Beibei   +8 more
core   +4 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Aquatic food security:insights into challenges and solutions from an analysis of interactions between fisheries, aquaculture, food safety, human health, fish and human welfare, economy and environment [PDF]

, 2016
Fisheries and aquaculture production, imports, exports and equitability of distribution determine the supply of aquatic food to people. Aquatic food security is achieved when a food supply is sufficient, safe, sustainable, shockproof and sound ...
AB Associates, Agnew D.J., Allison E.H., Anon, Anon, Bagnis R., Black K.D., Braithwaite V., CDC, EA, FSA, NIEA, NRW and SEPA, EC, EC, EC, EC, EC, EC, EC, EC, EC, EC, EC, EC, EC, Ellis T., Enghoff I.B., European Food Safety Authority, European Market Observatory for Fisheries and Aquaculture Products, FAO, FAO, FAO, FAO, FAO, Farm Animal Welfare Committee, FDA, Food Standards Agency, Garcia S.M., Gil A., Hall S.J., Hallegraef G.M., Hart P.J., Health and Safety Executive, Health and Safety Executive, Higman W.A., Hixson S.M., ICES, IMF, International Labour Organisation, James M.A., Lambie‐Mumford H., Lambooija E., Maritime Accident Investigation Branch, Morgan O., National Crime Agency, National Toxicology Program, Neil D., Nesheim M.C., Papworth G.P., PHE‐FSA, Robb D.F.H., Roberts S.E., Roth B., Sainsbury's Supermarkets, Scientific Advisory Committee on Nutrition and Committee on Toxicity, Scottish Government, Seafish, Seafish, Seafish, Shepherd C.J., SOCA, STECF, STECF, Trussell Trust, Turner R.K., Turner R.K., UK Government, UK Government, UK Government, UK Government, UK Government, UK Government, UK Government, UK Government, Verner‐Jeffreys D.W., Warner K., World Commission on Environment and Development, World Health Organization   +85 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source