Results 71 to 80 of about 4,141,356 (297)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Initial Imaging of Pregnant Patients in the Trauma Bay—Discussion and Review of Presentations at a Level-1 Trauma Centre

Diagnostics
Trauma is the leading non-obstetric cause of maternal and fetal mortality and affects an estimated 5–7% of all pregnancies. Pregnant women, thankfully, are a small subset of patients presenting in the trauma bay, but they do have distinctive physiologic ...
Roisin MacDermott, Ferco H. Berger, Andrea Phillips, Jason A. Robins, Michael E. O’Keeffe, Rawan Abu Mughli, David B. MacLean, Grace Liu, Heather Heipel, Avery B. Nathens, Sadia Raheez Qamar   +10 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Safety of Patient-Controlled Analgesia After Surgery in Children And Adolescents: Concerns And Potential Solutions

Frontiers in Pediatrics, 2018
Patient-controlled analgesia (PCA) is common practice for acute postoperative pain management. Postoperative PCA use decreases pain intensity and improves patient satisfaction when compared to non-PCA routes of medication administration. Although PCA has
Don Daniel Ocay, Don Daniel Ocay, Annik Otis, Annik Otis, Alisson R. Teles, Alisson R. Teles, Catherine E. Ferland, Catherine E. Ferland, Catherine E. Ferland, Catherine E. Ferland, Catherine E. Ferland, Catherine E. Ferland   +11 more
doaj   +1 more source

INTERNATIONAL IMPORTS AND THE SAFETY OF THE U.S. FOOD AND FIBER SYSTEM [PDF]

The trend towards globalization has led an increase in the U.S. Food trade. Threats of bio-terrorism and safety of the agriculture production system have become larger concerns to U.S consumers and policy makers.
Jimenez, Mariano, Salnars, Christian, VanSickle, John J.   +2 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Occurrence, Dietary Exposure Scenarios and Risk Assessment of Aflatoxins from Dried Fruits and Chocolates in Armenia

Foods
This study aimed to estimate dietary exposure to aflatoxins (AFs) and characterize its associated risks through the consumption of dried fruits and chocolates among the adult population of Yerevan, the capital city of Armenia.
Davit Pipoyan, Meline Beglaryan, Yepraqsya Arshakyan, Bagrat Harutyunyan   +3 more
doaj   +1 more source

Service user and carer involvement in mental health care safety: raising concerns and improving the safety of services

BMC Health Services Research, 2018
Background Previous research into improving patient safety has emphasised the importance of responding to and learning from concerns raised by service users and carers.
Kathryn Berzins, Gemma Louch, Mark Brown, Jane K. O’Hara, John Baker   +4 more
doaj   +1 more source

Landscape of AI Safety Concerns - A Methodology to Support Safety Assurance for AI-Based Autonomous Systems

501510Artificial Intelligence (AI) has emerged as a key technology, driving advancements across a range of applications. Its integration into modern autonomous systems requires assuring safety.
Theodorou, Konstantinos, Schnitzer, Ronald, Zillner, Sonja, Kilian, Lennart, Roessner, Simon   +4 more
core   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source