Results 31 to 40 of about 491,649 (265)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Safe Behavior at Work: Bibliometric Mapping of Conceptual Evolution and Trends (1957-2022)
Revista Psicologia, 2023 Safety behavior in the workplace encompasses a broad range of psychological, sociocultural, organizational, and technological factors that influence individual behavior.
Jose Jorge Ramirez-Landaeta +1 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Journal of Community Hospital Internal Medicine Perspectives, 2020 Background Patient safety events (PSE) are opportunities to improve patient care but physicians rarely report them. In a previous study, residents identified knowledge regarding what constitutes a PSE, perceived lack of time, complexity of the reporting ...
Mukul Singal +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Safety and Health Perceptions in Work-related Transport Activities in Ghanaian Industries
Safety and Health at Work, 2017 Background: With the recent rapid industrialization, occupational safety and health (OSH) has become an important issue in all industrial and human activities.
Charles Atombo +4 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Leadership Style and Safety Culture in Commuter Railroads
SafetyPrevious research has repeatedly demonstrated the importance of both safety culture and leadership in promoting workplace safety. Several studies and reviews have identified transformational leadership style as an important contributor to a strong safety
Patrick Sherry
doaj +1 more source
SWISS CHEESE IN BRAZIL: DISASTER CULTURE AND SAFETY CULTURE IN DISASTERS [PDF]
Ambiente & SociedadeThis article discusses points related to “disaster culture” and “safety culture” in Brazil, and debates how societal-structural factors influence the management of low incidence and high consequence disasters, such as dam breaks, which appear to provide ...
JEROEN WARNER +2 more
doaj +4 more sources