Results 91 to 100 of about 1,174,768 (293)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

open access: yesAging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang   +3 more
wiley   +1 more source

Evaluation of automated driving safety in urban mixed traffic environments

open access: yesIET Intelligent Transport Systems
Conflicting driving behaviours between automated vehicles and manually driven vehicles may compromise driving safety. The aim of this study is to analyse the safety of mixed traffic on urban roads.
Sangjae Lee   +4 more
doaj   +1 more source

Research on Evaluation Model for Secondary Task Driving Safety Based on Driver Eye Movements

open access: yesAdvances in Mechanical Engineering, 2014
This study was designed to gain insight into the influence of performing different types of secondary task while driving on driver eye movements and to build a safety evaluation model for secondary task driving.
Lisheng Jin   +5 more
doaj   +1 more source

Influencing driver behaviour through road marking [PDF]

open access: yes, 2005
This paper will describe how road marking can be used to influence driver behaviour in order to improve road safety and traffic flows. Extensive use will be made of examples from recent research undertaken by the authors on overtaking lane design, speed ...
Baas, Peter H., Charlton, Samuel G.
core   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin   +11 more
wiley   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman   +9 more
wiley   +1 more source

Leading the Worldwide Movement to Improve Road Safety [PDF]

open access: yes, 2013
Bloomberg Philanthropies' $125 million, five-year Global Road Safety program is aimed at reducing preventable road traffic deaths and injuries in ten countries through initiatives including increased seat-belt and helmet usage, reduced speed limits ...

core  

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi   +19 more
wiley   +1 more source

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