Results 101 to 110 of about 3,112,326 (355)

Genotoxicological Safety Evaluation of the Solvent Extracts for Medicinal Herbs that are of Highly Domestic Spendings [PDF]

, 2013
Won Ho Yoon
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Hazard evaluation of ground potential difference within grounding grid on personal safety under impulse current [PDF]

, 2021
Chun Li, Xishan Wen, Lei Guo, Jiafeng Chen, Jiahao Chen, Hailiang Lu   +5 more
openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Monitoring of veterinary drug residues in livestock products with antimicrobial resistance

Applied Biological Chemistry
Antimicrobial resistance (AMR) in animal-derived products remains a global concern, while reports on veterinary drug (VD) residues in such products are relatively rare.
Dahae Park, Yu Ra Kim, Ji Young Kim, Jang-Duck Choi, Guiim Moon, Dong Woo Shin   +5 more
doaj   +1 more source

Comparative clinical evaluation of safety and efficacy of commonly used drug-eluting stents in coronary artery disease patients after angioplasty in South India: A retro-prospective multi-center study [PDF]

, 2019
Vinoth Prabhu Veeramani, Saranya Selvam, Ahmed M. Hamdan, Vinoth Prabhu Veeramani, M Barton, J Gruntzig, M Husmann, J Rosch, E Benjamin, M Blaha, S Chiuve, M Cushman, S Das, R Deo, S De Ferranti, J Floyd, M Fornage, C Gillespie, C Isasi, M Jimenez, L Jordan, S Judd, D Lackland, J Lichtman, L Lisabeth, S Liu, C Longenecker, R Mackey, K Matsushita, D Mozaffarian, M Mussolino, K Nasir, R Neumar, L Palaniappan, D Pandey, R Thiagarajan, M Reeves, M Ritchey, C Rodriguez, G Roth, W Rosamond, C Sasson, A Towfighi, C Tsao, M Turner, S Virani, J Voeks, J Willey, J Wilkins, J Wu, H Alger, S Wong, P Muntner, J Feinberg, E Nielsen, J Greenhalgh, J Hounsome, N Sethi, S Safi, C Gluud, J Jakobsen, R Gupta, W Kim, S Lee, S Park, Y Kim, S Yun, J Lee, D Park, S Kang, C Lee, J Lee, S Choi, I Seong, B Lee, N Lee, Y Cho, W Shin, S Lee, S Lee, M Hyon, D Bang, W Park, H Kim, J Chae, K Lee, H Park, C Park, S Lee, M Kim, K Park, Y Choi, S Cheong, T Yang, J Jang, S Her, S Park, P Karjalainen, A Ylitalo, J Airaksinen   +99 more
openalex   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Evaluation of the functional results and safety of early removal of the urethral catheter after laparoscopic radical prostatectomy

, 2022
С. В. Котов, Р. И. Гуспанов, I. Sh. Byadretdinov, M. A. Ryabov, S. A. Pulbere, A. G. Yusufov, M. S. Zhilov   +6 more
openalex   +1 more source

Demonstrating adequate safety for a concrete column exposed to fire, using probabilistic methods [PDF]

, 2019
Demonstrating adequate safety for exceptional designs and new design applications requires an explicit evaluation of the safety level, considering the uncertainties associated with the design. The recently published PD 7974-7:2019 provides five routes to
Elhami Khorasani, Negar, Gernay, Thomas, Hopkin, Danny, Van Coile, Ruben   +3 more
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