Results 111 to 120 of about 3,112,326 (355)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Physiological platelet aggregation assay to mitigate drug-induced thrombocytopenia using a microphysiological system

Scientific Reports
Developing a reliable method to predict thrombocytopenia is imperative in drug discovery. Here, we establish an assay using a microphysiological system (MPS) to recapitulate the in-vivo mechanisms of platelet aggregation and adhesion.
Kosuke Harada, Wang Wenlong, Tadahiro Shinozawa   +2 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Establishment of the Standard System for Evaluating the Effectiveness of Emergency Response to Food Safety Emergencies: A Delphi Consensus Study

, 2022
Jun FANG, Jiaming Qu, Aijun ZHANG, Dan Wu, Zuojing Li, Zhenyu Sui   +5 more
openalex   +2 more sources

Schools in the Community: Action Research on Safety (SCARS) Project. Deliverable Number 2, Report on Before Surveys [PDF]

, 1996
This document represents the second deliverable of the Schools in the Community: Action Research on Safety (SCARS) project. The project is a joint one between Leeds City Council's Road Safety Promotion Unit (RSPU), the Faculty of Health and Social Care ...
Page, M., Dixey, R.
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The crystal structure of methyl 4-(4-(methylsulfonyl)phenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, C19H21NO5S

Zeitschrift für Kristallographie - New Crystal Structures
C19H21NO5S, triclinic, P1̄ (no. 2), a = 8.428(2) Å, b = 10.638(3) Å, c = 11.177(3) Å, α = 63.125(4)∘, β = 77.819(4)∘, γ = 79.845(4)∘, V = 869.9(4) Å3, Z = 2, R gt (F) = 0.0472, wR ref (F 2 ) = 0.1379, T = 296(2) K.
Li Yaoyao, Su Lai, Wang Tianqin, Zhang Le   +3 more
doaj   +1 more source

Measuring the Value of a Statistical Life: Problems and Prospects [PDF]

Tradeoffs between monetary wealth and fatal safety risks are summarized in the value of a statistical life (VSL), a measure that is widely used for the evaluation of public policies in medicine, the environment, and transportation safety.
Ashenfelter, Orley
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Research on Joint Optimization of Reserve and Dispatching for Multivariety Emergency Materials Based on NSGA-II

Discrete Dynamics in Nature and Society
Emergency material reserve and dispatching are important measures to reduce casualties and property losses after natural disasters occur. However, there has not yet been research that optimizes both the reserve and distribution of emergency materials ...
Xi Zhu, Kai Yao, Aiqiang Guo, Tianpeng Li, Weiyi Wu, Xinbao Gao   +5 more
doaj   +1 more source