Results 111 to 120 of about 19,469,886 (406)

A follow-up study of a randomized controlled study evaluating safety and efficacy of leuprorelin acetate every-3-month depot for 2 versus 3 or more years with tamoxifen for 5 years as adjuvant treatment in premenopausal patients with endocrine-responsive breast cancer [PDF]

, 2021
Junichi Kurebayashi, Eiichi Shiba, Tatsuya Toyama, Hiroshi Matsumoto, M. Okazaki, Tadashi Nomizu, Tohru Ohtake, Takaaki Fujii, Yasuo Ohashi   +8 more
openalex   +1 more source

Preliminary hazards summary for Nerva irradiation testing at Plum Brook Reactor Facility [PDF]

Safety hazard evaluation for irradiation testing in simulated NERVA environment at cryogenic ...

core   +1 more source

Pilot Safety Evaluation of Varenicline for the Treatment of Methamphetamine Dependence. [PDF]

, 2009
Despite the worldwide extent of methamphetamine dependence, no medication has been shown to effectively treat afflicted individuals. One relatively unexplored approach is modulation of cholinergic system function.
Clement, Clayton, De La Garza, Richard, London, Edythe D, Miotto, Karen, Newton, Thomas F, Sevak, Rajkumar J, Shoptaw, Steven, Swanson, Aimee-Noelle, Zorick, Todd   +8 more
core  

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Repeated-dose toxicity and immunogenicity evaluation of a recombinant subunit COVID-19 vaccine (ZF2001) in rats

Frontiers in Cellular and Infection Microbiology
Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), had given rise to a massive epidemic. Owing to the high morbidity and mortality of COVID-19 and the lack of effective therapies, safe and effective
Ruimin Sun, Ruimin Sun, Lijuan Xia, Lijuan Xia, Guangbiao She, Guangbiao She, Jinrong Li, Yiru Wang, Yiru Wang, Yunxiang Chen, Yunxiang Chen, Qian Yang, Siming Zhang, Fang Liu, Ying Chen, Liyan Zhang, Chengda Zhang, Wanqiang Lv, Wanqiang Lv, Enqi Huang, Enqi Huang, Lijiang Zhang, Lijiang Zhang, Lijiang Zhang   +23 more
doaj   +1 more source

The PK–PD Relationship and Resistance Development of Danofloxacin against Mycoplasma gallisepticum in An In Vivo Infection Model

Frontiers in Microbiology, 2017
Mycoplasma gallisepticum is the causative agent of chronic respiratory disease (CRD), a prevalent disease of poultry, which is responsible for significant economic losses in farms.
Nan Zhang, Yuzhi Wu, Zilong Huang, Lihua Yao, Longfei Zhang, Qinren Cai, Xiangguang Shen, Hongxia Jiang, Huanzhong Ding   +8 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

An exhaustive examination of the research progress in identifying potential JAK inhibitors from natural products: a comprehensive overview

Chinese Medicine
The JAK-STAT signaling pathway serves as a central regulator of diverse cellular processes encompassing proliferation, apoptosis, inflammation, and differentiation.
Wendong Yang, Jiabin Lu, Peihua Luo, Zhifei Xu, Hao Yan, Bo Yang, Qiaojun He, Jialin Zhou, Xiaochun Yang   +8 more
doaj   +1 more source

Gaseous Releases Evaluation and Safety Performance Improvement of Kartini Research Reactor Ventilation System [PDF]

, 2011
GASEOUS RELEASES EVALUATION AND SAFETY PERFORMANCE IMPROVEMENT OF KARTINI RESEARCH REACTOR VENTILATION SYSTEM. The safety performance of Kartini research reactor related to the gaseous releases to the environment has been evaluated.
Kusuma, H. (Hadi), Susyanta, W. (Widyatmaka), Syarip, S. (Syarip)   +2 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source