Results 271 to 280 of about 1,128,069 (317)
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Safety evaluation of tirofiban
Expert Opinion on Drug Safety, 2010Heightened platelet activity is pivotal in the thrombosis underlying acute coronary syndrome (ACS). The glycoprotein IIb/IIIa inhibitor tirofiban is a powerful platelet inhibitor with demonstrated efficacy and safety across the spectrum of ACS. Despite tirofiban's impact on the platelet compared with placebo, only an excess in minor and importantly not
Marco, Valgimigli, Matteo, Tebaldi
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Safety evaluation of fibermalt
Food and Chemical Toxicology, 2012Fibermalt is a new soluble fiber food ingredient produced with the use of an alternansucrase enzyme from Leuconostoc mesenteroides expressed in a non-pathogenic strain of Escherichia coli. Fibermalt is predominantly composed of indigestible maltose alternan oligosaccharides (≥ 80%). Fibermalt was non-mutagenic in a bacterial reverse mutation test. In a
Laurie C, Dolan +5 more
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Evaluation of safety for flibanserin
Expert Opinion on Drug Safety, 2019Introduction: Hypoactive sexual desire disorder (HSDD) is the most prevalent sexual dysfunction in women, previously managed with off-label therapies. Indicated for premenopausal women, flibanserin is the first FDA-approved medication to treat HSDD.Areas covered: This review summarizes flibanserin's pharmacokinetics, proposed mechanism of action, and ...
Anita H, Clayton +2 more
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Safety evaluation of benzophenone
Food and Chemical Toxicology, 1991Benzophenone (FEMA No. 2134; CAS No. 119-61-9) was administered in the diet to rats at target dose levels of 20 mg/kg body weight/day for 90 days and 100 or 500 mg/kg/day for 28 days. Body weights and food consumption were measured weekly; haematology, clinical chemistry and urinalysis values were obtained at 4 wk and at the end of the study. Gross and
G A, Burdock, D H, Pence, R A, Ford
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2013
Before pharmaceutical products are evaluated in humans, it is essential that they undergo a rigorous safety assessment using in vitro models and studies in preclinical species. Once products progress into the clinic, additional preclinical studies are needed to support further clinical testing.
Jonathon D S, Holt, Jeremy P, Nuttall
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Before pharmaceutical products are evaluated in humans, it is essential that they undergo a rigorous safety assessment using in vitro models and studies in preclinical species. Once products progress into the clinic, additional preclinical studies are needed to support further clinical testing.
Jonathon D S, Holt, Jeremy P, Nuttall
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Safety evaluation of preservatives
International Journal of Cosmetic Science, 1997Les conservateurs sont ajoutes aux produits cosmetiques pour augmenter leur duree de vie, en les protegeant contre une contamination microbienne qui sans cela les degraderait et exposerait le consommateur a un danger d'infection. Malgre tout, les conservateurs sont des produits chimiques biologiquement actifs qui exposent aussi le consommateur a des ...
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Evaluation of the safety of isoxicam
The American Journal of Medicine, 1985Data collected from more than 1,800 patients with rheumatoid arthritis or degenerative joint disease in Phase 3 clinical studies of isoxicam (Maxicam) indicated that the drug is well tolerated on both a short-term and a long-term basis. The most common type of adverse reaction to all medications (isoxicam, aspirin, and indomethacin) was ...
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Challenges of safety evaluation
Journal of Ethnopharmacology, 2014Each application for authorisation of a medicinal product must be accompanied by the particulars and documents referred to in Directive 2001/83/EC on the Community code relating to medicinal products for human use. Details on the documentation needed for traditional herbal medicinal products (THMP) are given in article 16c of the above mentioned ...
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Safety evaluation of fenbendazole in swine
American Journal of Veterinary Research, 1983SUMMARY Thirty female pigs, average weight 32 kg, were given fenbendazole for 3 days to test the safety of the drug. Dosages of 0, 3, 9, 15, and 25 mg of active ingredient/kg of body weight were mixed with the feed. Chemical analysis, urinalysis, and hematologic, gross and microscopic pathologic, and bone marrow cytologic examinations revealed no ...
T F, Booze, F W, Oehme
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Tinospora cordifolia, a safety evaluation
Toxicology in Vitro, 2009Tinospora cordifolia is one of the indispensable medicinal plants used in veterinary folk medicine/Ayurvedic system of medicine for the treatment of diverse diseases and recommended for improving the immune system by means of body resistance. In the current study, we evaluated the genotoxic risk of the aqueous extract of T. cordifolia (TC) in a battery
C V, Chandrasekaran +3 more
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